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Utopia Talk / Politics / Genetics, covid and neandertals
Nimatzo
iChihuaha
Sun Jul 05 05:35:24
This is a pre-print, so it has not been reviewed yet.

Abstract

A recent genetic association study (Ellinghaus et al. 2020) identified a gene cluster on chromosome 3 as a risk locus for respiratory failure in SARS-CoV-2. Recent data comprising 3,199 hospitalized COVID-19 patients and controls reproduce this and find that it is the major genetic risk factor for severe SARS-CoV-2 infection and hospitalization (COVID-19 Host Genetics Initiative). Here, we show that the risk is conferred by a genomic segment of ~50 kb that is inherited from Neandertals and occurs at a frequency of ~30% in south Asia and ~8% in Europe.

http://www.biorxiv.org/content/10.1101/2020.07.03.186296v1
Hrothgar
Member
Sun Jul 05 14:54:05
Interesting, but this seems flawed with reality where the largest deaths per 100k of population are coming from people with darker skin. Possible vitamin D deficiency situation. African and Latinos descendants don't have nearly as much neanderthal genetics as Asians/Europeans.

http://www.apmresearchlab.org/covid/deaths-by-race
Nimatzo
iChihuaha
Sun Jul 05 15:31:15
It’s not an either or thing. Groups can still die at higher rate from covid for other reasons. Like vitamim D, social patterns and other genetic factors.
Nimatzo
iChihuaha
Sun Jul 05 15:33:31
It’s about risks and the study claims to have identified a genetic risk factor. If true it would be wise that it be included in the calculation.
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