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The current time is Tue Aug 11 02:25:40 2020

Utopia Talk / Politics / Genetics, covid and neandertals
Sun Jul 05 05:35:24
This is a pre-print, so it has not been reviewed yet.


A recent genetic association study (Ellinghaus et al. 2020) identified a gene cluster on chromosome 3 as a risk locus for respiratory failure in SARS-CoV-2. Recent data comprising 3,199 hospitalized COVID-19 patients and controls reproduce this and find that it is the major genetic risk factor for severe SARS-CoV-2 infection and hospitalization (COVID-19 Host Genetics Initiative). Here, we show that the risk is conferred by a genomic segment of ~50 kb that is inherited from Neandertals and occurs at a frequency of ~30% in south Asia and ~8% in Europe.

Sun Jul 05 14:54:05
Interesting, but this seems flawed with reality where the largest deaths per 100k of population are coming from people with darker skin. Possible vitamin D deficiency situation. African and Latinos descendants don't have nearly as much neanderthal genetics as Asians/Europeans.

Sun Jul 05 15:31:15
It’s not an either or thing. Groups can still die at higher rate from covid for other reasons. Like vitamim D, social patterns and other genetic factors.
Sun Jul 05 15:33:31
It’s about risks and the study claims to have identified a genetic risk factor. If true it would be wise that it be included in the calculation.
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