Utopia Talk / Politics / I was dehydrated

River of blood Member	Fri Sep 11 16:47:20 So I read on this conspiracy whacko site that if I just drank some water I wouldn't be dehydrated anymore. So I tried it just for shits and grins and miraculuously it worked! How is this possible? Shouldn't I have had to go to the hospital and get all my dehydrated organs transplanted with hyrdrated ones for 37 million dollars?
Dead Idiot New Member	Fri Sep 11 16:59:06 I had AIDS, so I went online and saw on this awesome website that if I drink water (and I already have drank water daily), I would be magically cured. But then I died. Oh well. Must be a government conspiracy that killed me.
Milton Bradley Member	Fri Sep 11 17:04:48 If dehydration were a disease, I guess this thread might be relevant.
Wayne Bollman Member	Fri Sep 11 17:07:10 Acually, dead idiot, no wonder youre a dead idiot. The water you drank should have contained a microscopic amount of hiv for that to work. GG dumbass
Wayne Bollman Member	Fri Sep 11 17:07:40 Dehydration IS a disease
River of blood Member	Fri Sep 11 18:05:24 "Disease: a condition of the living animal or plant body or of one of its parts that impairs normal functioning and is typically manifested by distinguishing signs and symptoms" http://www.merriam-webster.com/dictionary/disease "If dehydration were a disease, I guess this thread might be relevant." Fall on your sword.
freaky boy Member	Fri Sep 11 18:51:03 well listen up now boys, I have suffered dehydration. When I arrived at the hospital, after a month of slowly dehydrating, the doctor said I was about 2 or 3 days away from death by kidney failure. this is about 4 years ago, it started with a cold. because I was working in a meat works, and my job involved walking around the plant, from one temperature zone to another - 20 to 10 to minus 5 degrees centigrade, and back again, I could not shake this cold (usualy a cold lasts no more than a week, but I was sick for 3 weeks straight, but I kept on working) so I ended up overdosing on cold and flu medication, which is an extringent, I was drinking overproof rum at nite to get some sleep. as my body dehydrated, and I kept walking, my muscle tissue to began to break down, releasing toxins into the blood stream, I became increasingly week, so I started using pick me up pills, like cafiene no dose, and guarana boost pills. this only exacerbated the dehydration. in the final days, I started losing my ballance, I was delirious, and finaly was admitted to hospital. I had to spend 2 days on a drip just to replenish my fluids. dehydration is no joke, it has both physical and psycological effects, and is really quite unpleasant. its symptoms are much like a disease, and the damage it causes to the mind and body is no larfing matter. Im not entirely sure what this ongoing gag is all about - but theres my story, and its no bull.
yankeessuck123 Member	Fri Sep 11 20:08:58 Not to get involved in this retarded shitfest, but that definition is wrong. A disease is caused by bacteria or a virus, and is generally transmittable by some means. Dehydration is a 'condition', at best. Now fuck off.
Canadian Member	Fri Sep 11 20:56:41 "I was dehydrated" - Billah recommends that you drink one quart of hippie piss to cure yourself.
Nimatzo Member	Fri Sep 11 21:57:06 A disease does not need to be caused by a bacteria or a virus f.ex Cancer, Alzheimer etc. Though RoB is a retard we can agree on that.
stream of blood Member	Sat Sep 12 01:14:26 anything that goes against the medical-pharmaceutical-industrial complex is automatically rejected by most of the people on this board. most drugs are just overpriced sugarpills yet these guys fall for it because some brainiac "doctor" with a piece of paper from a med school tells them that they need it. ask yourselves this, would you need it if they didn't force it upon you?
River of blood Member	Sat Sep 12 10:28:20 "Not to get involved in this retarded shitfest, but that definition is wrong. A disease is caused by bacteria or a virus..." LOL. Fucking idiot.
River of blood Member	Sat Sep 12 10:38:48 Here is the definition from a MEDICAL dictionary: http://medical-dictionary.thefreedictionary.com/disease disease /dis·ease/ (dÄ­-zÄ?z´) any deviation from or interruption of the normal structure or function of any body part, organ, or system that is manifested by a characteristic set of symptoms and signs and whose etiology, pathology, and prognosis may be known or unknown. Example: Dehydration
River of blood Member	Sat Sep 12 10:39:19 You see anything in there about viruses or bacteria?
roland Member	Sat Sep 12 10:41:25 Someone hit you in the head is a disease then. Quick, everyone grab a cup of water.
River of blood Member	Sat Sep 12 11:02:36 Yes, let's see how your body heals from head wounds when you are completely dehydrated. Oh wait, that's right, it can't.
Asgard Member	Sat Sep 12 11:14:42 RoB, did you write the script for Signs?
ehcks Member	Sat Sep 12 11:51:43 You choosing to not drink enough is not a disease.
River of blood Member	Sat Sep 12 22:25:24 It is if you're schizo and think that water is trying to kill you. And I never said that not drinking enough water is not a disease - nice strawman there, idiot. I said being DEHYDRATED is a disease and it obviously is. Having sex with someone that has AIDS is not a disease either. What's your point?
Camaban Moderator	Sat Sep 12 22:26:35 A stubbed toe is a disease.
roland Member	Sat Sep 12 22:41:44 "It is if you're schizo and think that water is trying to kill you." Schizophrenia is a disease, not drinking water is the consequence of the disease. If you're schizo and trying to kill yourself by jumping out of a tall building. Jumping out of a tall building is NOT a disease. Schizophrenia is. "Having sex with someone that has AIDS is not a disease either. What's your point? " Correct, having sex is not a disease, having sex with someone that has AIDS is not a disease. It only help spreading the disease. So far, you failed at all the analogies you used... but, nice try though.
Nimatzo Member	Sun Sep 13 06:05:19 Dehydration is a >disease state<. It is not refereed to as a disease within the medical community as it often is the result/symptom of some other disease or affliction. Yes I actually asked the doctor since last time.
Cthulhu Member	Sun Sep 13 08:08:19 'Not to get involved in this retarded shitfest, but that definition is wrong. A disease is caused by bacteria or a virus, and is generally transmittable by some means. Dehydration is a 'condition', at best. Now fuck off. ' Or Genetic problems.
licker Sports Mod	Sun Sep 13 08:59:41 So being a redneck is a disease now?
river of blood Member	Sun Sep 13 11:01:04 Is it a deviation from or interruption of the normal structure or function of any body part, organ, or system that is manifested by a characteristic set of symptoms and signs and whose etiology, pathology, and prognosis may be known or unknown? I'm going to say no on this one. But obviously YES on dehydration.
Asgard Member	Sun Sep 13 11:05:37 RoB... perhaps drinking water can cure a man who was shot in the head's dehydration, but it can't cure his gunshot wound. Do you understand this logic? drinking water can only help the body to remain functional, but not add help to the healing of a gunshot wound. How stupid are you?
river of blood Member	Sun Sep 13 11:10:42 Moron, your blood has to have water in it to do the hundreds of different things it does including making platelets which clot your blood to stop wounds from bleeding. I love it when someone tried to debate me on a subject they know absolutely nothing about and don't even KNOW that they know absolutely nothing about it.
river of blood Member	Sun Sep 13 11:11:53 Why are all of you always wrong about every health/medical subject that comes up? UP is like a repository for health retards.
Asgard Member	Sun Sep 13 11:18:10 "Moron, your blood has to have water in it to do the hundreds of different things it does including making platelets which clot your blood to stop wounds from bleeding." Like I said: drinking water can only help the body to remain functional explain to me how water ADDS to the body's natural ability to heal?
Nimatzo Member	Sun Sep 13 11:19:28 RoB is actually arguing that without water we couldn't survive. That is what his entire platform has been reduced too. Pathetic.
river of blood Member	Sun Sep 13 12:04:57 "explain to me how water ADDS to the body's natural ability to heal?" It doesn't just ADD to it, asshat. It's and essential ingredient in healing. Any MD or health practioner can tell you this: http://rn....le/articleDetail.jsp?id=114164 "Feeding your patient to help him heal .....Water is essential for cells to function normally. Water balance, or hydration, is present when a patient's fluid intake equals his output. Dehydration occurs when a patient doesn't receive enough fluid, or when fluid loss exceeds intake. Dehydration reduces blood volume, which further decreases circulation and reduces oxygen and nutrient delivery to the tissues. To help ensure that a patient is properly hydrated, 30 â?? 35 ml of fluid per kg of body weight per day may be adequate unless contraindicated." "drinking water can only help the body to remain functional" And how were you planning on having your body heal itself if it's healing mechanisms aren't functional? Duheeeeeeee......
river of blood Member	Sun Sep 13 12:13:03 www.floridalmsc.org/Newsletter_archive/bodyheal.pdf "As adequate hydration is CRUCIAL to wound healing, patients should be encouraged to drink two to three quarts of quality water daily during the healing ..."
river of blood Member	Sun Sep 13 12:15:02 http://www...in/mwf/topic_show.pl?tid=10393 "You also should continue the water after surgery for continued removal of these substances, as well as facilitating your healing"
ehcks Member	Sun Sep 13 12:16:34 But the water isn't what cures the wounds or diseases. It's just a mandatory chemical you need. Your body needs Vitamin C. One does not say Vitamin C cures scurvy, but that a lack of Vitamin C causes scurvy. Same with water and dehydration.
river of blood Member	Sun Sep 13 12:17:51 What cures scurvy then retard? Nothing?
river of blood Member	Sun Sep 13 12:18:41 Amzing how everyone in the world seems to know that your body needs water to heal itself except some douchbags on UP.
river of blood Member	Sun Sep 13 12:22:29 "One does not say Vitamin C cures scurvy," http://emedicine.medscape.com/article/985573-overview "In 1746, James Lind, a British naval surgeon, established the fact that oranges and lemons were effective in curing scurvy"
ehcks Member	Sun Sep 13 12:22:59 You don't "cure" a lack of a nutrient except by restoring the correct level of that nutrient. Your idea is like thanking the government for giving you $300 after making you broke for your entire life. Argue against that.
river of blood Member	Sun Sep 13 12:28:54 http://www...and-human-disease-1015602.html "However, we do know of one natural cure that has withstood the test of time and science for one such disease. The disease is scurvy and the â??cureâ?? for scurvy is the commonly known natural substance Vitamin C"
River of mud Member	Sun Sep 13 12:31:37 Vitamin C not only cures aids but also, crushed skulls, severed limbs and other similar diseases.
river of blood Member	Sun Sep 13 12:31:54 http://www...ticlerender.fcgi?artid=2647905 "Vitamin C was responsible for the cure of scurvy......"
river of blood Member	Sun Sep 13 12:34:11 http://www.faqs.org/health/bios/33/James-Lind.html "Others refused to believe that any disease as bad as scurvy could be CURED so easily with an orange a day. In the next year, 1795,the Royal Navy adopted the practice of giving seamen citrus fruits and juicesas part of their diets. Scurvy promptly vanished from the Royal Navy."
river of blood Member	Sun Sep 13 12:35:11 And now it appears that everyone in the world understands tha vitamin C CURES scurvy except for the retard known as ehcks.
river of blood Member	Sun Sep 13 12:37:35 "Your body needs Vitamin C. One does not say Vitamin C cures scurvy," - ehcks "Vitamin C cures scurvy." - every MD and health practioner on the planet
river of blood Member	Sun Sep 13 12:41:52 I accidently cut myself open the other day. I went to get the wound stitched up. But the stitches didn't help "heal" my wound, they were just something I needed. - That's the logic of ehcks
river of blood Member	Sun Sep 13 12:44:19 And where did asgard run off to? Oh that's right, he got his ass handed to him on that water debate.
ehcks Member	Sun Sep 13 12:46:05 Talking to you is like talking to a brick wall with stupid graffiti on it.
river of blood Member	Sun Sep 13 13:09:57 What cures scurvy, ehcks? Anything?
river of blood Member	Sun Sep 13 13:10:46 Surgery maybe? LOL
ehcks Member	Sun Sep 13 13:17:49 What I want to know is what cures stupidity. You need quite a few doses.
river of blood Member	Sun Sep 13 13:20:23 "Dehydration is a >disease state<. It is not refereed to as a disease within the medical community..." HUGE eye roll. "....as it often is the result/symptom of some other disease or affliction." So is AIDS. AIDS isn't a disease now either? Or referred to as such in the medical community? In fact isn't AIDS ALWAYS the result/symptom of another disease (HIV), not just "often".
river of blood Member	Sun Sep 13 13:21:22 Ehcks, does vitamin C cure scurvy?
hoER Member	Sun Sep 13 13:29:24 They got scurvy because of vitamin c deficiency. Once they cured the deficiency, scurvy did not evolve.
Formerly Fred Member	Sun Sep 13 13:31:27 Evolve? WTF would scurvy evolve into?
hoER Member	Sun Sep 13 13:32:48 ok, develop, or whatever. We're not submitting articles to the lancet here.
river of blood Member	Sun Sep 13 13:41:26 "They got scurvy because of vitamin c deficiency. Once they cured the deficiency, scurvy did not evolve." The tourniquet on my gushing wound didn't stop my bleeding; the preasure that it APPLIED stopped it. No wait, it wasn't the pressure that stopped it, it was the blood vessels closing up FROM the preasure that stopped it. No wait...... Fucking kill yourself.
river of blood Member	Sun Sep 13 13:42:12 preasure = pressure
hoER Member	Sun Sep 13 13:43:06 torniquet is not an essential part of your bodys daily diet.
river of blood Member	Sun Sep 13 13:45:34 So?
hoER Member	Sun Sep 13 13:46:52 hence you dont get sick from having a torniquet deficiency. Not a good comparison.
river of blood Member	Sun Sep 13 13:47:36 I shot someone and killed them. No wait, *I* didn't kill them, the gun did. No wait, the gun didn't kill them, the bullet did. No wait, the bullet didn't kill them, the bleeding hole did. No wait.......
river of blood Member	Sun Sep 13 14:57:27 Just let me make sure I'm understanding you correctly before I bust out laughing again. Because vitamin C is something that your body needs in general, it cannot be a cure for scurvy? Do I have that right?
river of blood Member	Sun Sep 13 16:57:25 yep next
Nimatzo Member	Sun Sep 13 17:57:05 >>So is AIDS. AIDS isn't a disease now either? Or referred to as such in the medical community? In fact isn't AIDS ALWAYS the result/symptom of another disease (HIV), not just "often".<< HIV is not a disease you dumb ass, it is the name of the fucking virus that CAUSES the DISEASE AIDS.
River of blood Member	Sun Sep 13 19:04:41 "HIV is not a disease you dumb ass" - Nimatzo http://www.cdc.gov/nchhstp/blog/archive/090308.htm "HIV is a disease the affects the whole person...." http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1868408 "HIV is a disease...." https://www.epi.ufl.edu/?q=node/43 "HIV is a disease...." http://hab.hrsa.gov/publications/womencare05/WG05chap2.htm "HIV is a disease...." . . . . Gosh Nimatzo, the CDC, the NIH, the Department of Health and Human Services and every medical journal and health angency I can find online says it's a disease. Looks like maybe you're wrong.....again. LOL. Idiot.
Nimatzo Member	Sun Sep 13 19:21:50 Are these the part of the same government that you insist uses propaganda to scare people? Are you trusting them now? Fine, their misuse of the word disease to describe the Human immunodeficiency virus makes them as stupid as you. I am ok with that.
River of blood Member	Sun Sep 13 19:22:31 "Vitamin C doesn't cure scurvy" - Ehcks and hoER "HIV is not a disease" - Nimatzo "Water does not assist your body's ability to heal." - Assgard "Things that are not caused by bacteria or viruses (like alzheimers) are not diseases" - yankeesuck ---- Great thread so far guys. Anyone else having anything completely retarded to add so that I can prove them dead wrong again?
River of blood Member	Sun Sep 13 19:25:01 "Are these the part of the same government that you insist uses propaganda to scare people? Are you trusting them now? Fine, their misuse of the word disease to describe the Human immunodeficiency virus makes them as stupid as you. I am ok with that." So the entire medical establishment, health industry, AIDS organization, etc. are all wrong and YOU are right? Why do you call them all up with this huge news flash of yours about HIV not being a disease and correct them?
River of blood Member	Sun Sep 13 19:33:35 Oh I almost forgot one: "If a substance is needed for your body to function (like water or vitamins) then it cannot also cure anything. It's a law." - hoER Possibly the single dumbest thing I've ever heard anyone say about health anywhere ever.
ehcks Member	Sun Sep 13 19:51:04 Today, UP discovered that throwing factual information at a moron doesn't cure stupidity.
camaban Moderator	Sun Sep 13 20:02:57 A scratch I got yesterday is also a disease.
roland Member	Sun Sep 13 20:10:37 "Today, UP discovered that throwing factual information at a moron doesn't cure stupidity. " Today??
River of blood Member	Sun Sep 13 20:20:35 "Today, UP discovered that throwing factual information at a moron doesn't cure stupidity" You mean like when you said vitamin C doesn't cure scurvy and then I posted some mainstream links showing that the entire medical/health world says that it DOES cure scurvy and they've ackowledged this for 250 years.
River of blood Member	Sun Sep 13 20:56:49 .....and then you just ignored all that and called me stupid and ran away like a little girl?
Asgard Member	Sun Sep 13 21:38:18 You are walking in the desert, hiking. You stumble and break your thigh, tearing a major artery. You start bleeding fast. Your backpack with all the water is about 20 feet from you at the place you fell, but you're gonna have to crawl to get to it, and it would take time. time you don't neccesarily have, since you're bleeding. So you got two options: -take off your belt and tie it above the wound to stop the bleeding, as a tourniquet. a process that can take several minutes. -crawl to your backpack for the precious, curing water. a process that can take several minutes. which is it?
River of blood Member	Mon Sep 14 00:20:27 The tourniquet of course. What's your point?
Asgard Member	Mon Sep 14 02:38:04 My point is that water cures everything, it even cures artery wounds. Why not go for the water then?
River of blood Member	Mon Sep 14 09:26:41 Why do you keep insisting on putting forth this ridiculous strawman?
ehcks Member	Mon Sep 14 09:42:13 It's not a strawman if it's the entire point of your argument. Everyone here knows you're arguing for water being a cure for a disease because you're pro-homeopathy. Trying to claim that water with an imaginary level of a chemical that causes a disease actually cures it instead.
River of blood Member	Mon Sep 14 09:46:05 I am not "pro-homeopathy", I'm just not anti-homeopathy. It seems just at least as likely to work as 90% of the bullshit MDs try to do so I don't see what the big stink is. By the way ehcks, what cures scurvy? Anything?
ehcks Member	Mon Sep 14 09:49:22 A compound which a lack of causes an ailment does not then cure that same ailment. Anyone and EVERYONE who says it does is just simplifying it for morons like you.
River of blood Member	Mon Sep 14 09:57:03 "A compound which a lack of causes an ailment does not then cure that same ailment" LOL! That's EXACTLY what it does. That's how most real "CURES" work, idiot!! ZERO knowledge about health and medicine. ZERO. Keep posting please. Very entertaining.
ehcks Member	Mon Sep 14 09:57:06 It's called prevention, not curing. You don't cure scurvy with C, you prevent scurvy with C. You don't cure dehydration with water, you prevent it with water. If you already have it, you're still not curing it. You're preventing it from continuing, until such time that you stop preventing it again. If you cure a disease, it does not come back. It especially doesn't come back instantly after you remove the cure.
ehcks Member	Mon Sep 14 09:59:50 "That's how most real "CURES" work, idiot!!" No. This is retarded. You don't cure Polio, by, say, avoiding people with Polio. You already have it. You need actual medicine. You don't cure flues by avoiding people with the flu. You need actual medicine. You don't cure ANYTHING that way.
Nimatzo Member	Mon Sep 14 12:25:53 >>So the entire medical establishment, health industry, AIDS organization, etc.<< Just that it is not the entire medical establishment, but selected departments and institution in America, fat stupid America, where most people do not know where the capital is, where Liberal means communist, where Bush was elected twice and 90% of the population do not accept evolution. I really you are just another idiot in the fray and the fact that you refer to institutions and "establishments" you otherwise warn us about just shows how full of shit you are.
River of blood Member	Tue Sep 15 19:48:10 ehcks last replies are so off the charts retarded I'm not even sure how to respond to them. This alone makes this worth topping. ttt
president bush Member	Tue Oct 06 16:49:00 "So I read on this conspiracy whacko site that if I just drank some water I wouldn't be dehydrated anymore." You might call that a conspiracy whacko site, most of us would call that a sensible site.
River of blood Member	Tue Oct 06 16:55:02 Aaahhh yes, this old thread. One of my recent favorites. This is where echks says that there is no cure for scurvy, not even vitamin C..... and that if something is good for you in GENERAL then it's impossible for it to cure any diseases. LOL. Classic. Yes, keep this going.
roland Member	Tue Oct 06 16:56:30 do you have to dig up this thread?
River Of Failure Member	Tue Oct 06 16:59:04 http://img5.imageshack.us/img5/487/sealsl.gif
River of blood Member	Tue Oct 06 17:11:55 I didn't.
Atcha Member	Wed Oct 07 03:07:25 Thats hilarious. In RoB' "medical dictionary" definition, they have a huge list of everything they can think of...except dehydration...RoB had to write that one himself...lol disease /dis·ease/ (dÄ­-zÄ?z´) any deviation from or interruption of the normal structure or function of any body part, organ, or system that is manifested by a characteristic set of symptoms and signs and whose etiology, pathology, and prognosis may be known or unknown. See also entries under syndrome. acquired cystic disease of kidney the development of cysts in the formerly noncystic failing kidney in end-stage renal disease. Addison's disease bronzelike pigmentation of the skin, severe prostration, progressive anemia, low blood pressure, diarrhea, and digestive disturbance, due to adrenal hypofunction. Albers-Schönberg disease osteopetrosis. allogeneic disease graft-versus-host reaction occurring in immunosuppressed animals receiving injections of allogeneic lymphocytes. Alpers' disease a rare disease of young children, characterized by neuronal deterioration of the cerebral cortex and elsewhere, progressive mental deterioration, motor disturbances, seizures, and early death. alpha chain disease heavy chain disease characterized by plasma cell infiltration of the lamina propria of the small intestine resulting in malabsorption with diarrhea, abdominal pain, and weight loss, possibly accompanied by pulmonary involvement. Alzheimer's disease progressive degenerative disease of the brain, of unknown cause; characterized by diffuse atrophy throughout the cerebral cortex with distinctive histopathological changes. Andersen's disease glycogen storage d., type IV. apatite deposition disease a connective tissue disorder marked by deposition of hydroxyapatite crystals in one or more joints or bursae. Aran-Duchenne disease spinal muscular atrophy. arteriosclerotic cardiovascular disease (ASCVD) atherosclerotic involvement of arteries to the heart and to other organs, resulting in debility or death; sometimes used specifically for ischemic heart disease. arteriosclerotic heart disease (ASHD) ischemic heart d. autoimmune disease any of a group of disorders in which tissue injury is associated with humoral or cell-mediated responses to the body's own constituents; they may be systemic or organ-specific. Ayerza's disease polycythemia vera with chronic cyanosis, dyspnea, bronchitis, bronchiectasis, hepatosplenomegaly, bone marrow hyperplasia, and pulmonary artery sclerosis. Banti's disease congestive splenomegaly. Barlow disease scurvy in infants. Barraquer's disease partial lipodystrophy. Basedow's disease Graves' d. Batten disease , Batten-Mayou disease 1. Vogt-Spielmeyer d. 2. more generally, any or all of the group of disorders constituting neuronal ceroid lipofuscinosis. Bayle's disease general paresis. Bazin's disease erythema induratum. Bekhterev's (Bechterew's) disease ankylosing spondylitis. Benson's disease asteroid hyalosis. Berger's disease IgA glomerulonephritis. Bernhardt's disease , Bernhardt-Roth disease meralgia paresthetica. Besnier-Boeck disease sarcoidosis. Best's disease congenital macular degeneration. Bielschowsky-Janský disease Janský-Bielschowsky d. Binswanger's disease a degenerative dementia of presenile onset caused by demyelination of the subcortical white matter of the brain. black disease a fatal disease of sheep, and sometimes of humans, in the United States and Australia, due to Clostridium novyi, marked by necrotic areas in the liver. Blocq's disease astasia-abasia. Blount disease tibia vara. Boeck's disease sarcoidosis. Bornholm disease epidemic pleurodynia. Bowen's disease a squamous cell carcinoma in situ, often due to prolonged exposure to arsenic; usually occurring on sun-exposed areas of skin. The corresponding lesion on the glans penis is termed erythroplasia of Queyrat. Brill's disease Brill-Zinsser d. Brill-Symmers disease giant follicular lymphoma. Brill-Zinsser disease mild recrudescence of epidemic typhus years after the initial infection, because Rickettsia prowazekii has persisted in body tissue in an inactive state, with humans as the reservoir. broad beta disease familial dysbetalipoproteinemia; named for the electrophoretic mobility of the abnormal chylomicron and very-low-density lipoprotein remnants produced. Busse-Buschke disease cryptococcosis. Caffey's disease infantile cortical hyperostosis. calcium hydroxyapatite deposition disease apatite deposition d. calcium pyrophosphate deposition disease (CPDD) an acute or chronic inflammatory arthropathy caused by deposition of calcium pyrophosphate dihydrate (CPPD) crystals in the joints, chondrocalcinosis, and crystals in the synovial fluid. Acute attacks are sometimes called pseudogout. Calvé-Perthes disease osteochondrosis of capitular epiphysis of femur. Camurati-Engelmann disease diaphyseal dysplasia. Canavan disease , Canavan-van Bogaert-Bertrand disease spongy degeneration of the central nervous system. Carrión's disease bartonellosis. Castleman disease a benign or premalignant condition resembling lymphoma but without recognizable malignant cells; there are isolated masses of lymphoid tissue and lymph node hyperplasia, usually in the abdominal or mediastinal area. cat-scratch disease a usually benign, self-limited disease of the regional lymph nodes, caused by Bartonella henselae and characterized by a papule or pustule at the site of a cat scratch, subacute painful regional lymphadenitis, and mild fever. celiac disease a malabsorption syndrome precipitated by ingestion of gluten-containing foods, with loss of villous structure of the proximal intestinal mucosa, bulky, frothy diarrhea, abdominal distention, flatulence, weight loss, and vitamin and electrolyte depletion. Chagas disease trypanosomiasis due to Trypanosoma cruzi; its course may be acute, subacute, or chronic. Charcot-Marie-Tooth disease muscular atrophy of variable inheritance, beginning in the muscles supplied by the peroneal nerves and progressing to those of the hands and arms. cholesteryl ester storage disease (CESD) a lysosomal storage disease due to deficiency of lysosomal cholesterol esterase, variably characterized by some combination of hepatomegaly, hyperbetalipoproteinemia, and premature atherosclerosis. Christmas disease hemophilia B. chronic granulomatous disease frequent, severe infections of the skin, oral and intestinal mucosa, reticuloendothelial system, bones, lungs, and genitourinary tract associated with a genetically determined defect in the intracellular bactericidal function of leukocytes. chronic obstructive pulmonary disease (COPD) any disorder marked by persistent obstruction of bronchial air flow. Coats' disease exudative retinopathy. collagen disease any of a group of diseases characterized by widespread pathologic changes in connective tissue; they include lupus erythematosus, dermatomyositis, scleroderma, polyarteritis nodosa, thrombotic purpura, rheumatic fever, and rheumatoid arthritis. Cf. collagen disorder. communicable disease a disease the causative agents of which may pass or be carried from one person to another directly or indirectly. Concato's disease progressive malignant polyserositis with large effusions into the pericardium, pleura, and peritoneum. constitutional disease one involving a system of organs or one with widespread symptoms. Cori's disease glycogen storage d., type III. coronary artery disease (CAD) atherosclerosis of the coronary arteries, which may cause angina pectoris, myocardial infarction, and sudden death; risk factors include hypercholesterolemia, hypertension, smoking, diabetes mellitus, and low levels of high-density lipoproteins. coronary heart disease (CHD) ischemic heart d. Cowden disease a hereditary disease marked by multiple ectodermal, mesodermal, and endodermal nevoid and neoplastic anomalies. Creutzfeldt-Jakob disease a rare prion disease existing in sporadic, familial, and infectious forms, with onset usually in middle life, and having a wide variety of clinical and pathological features. The most commonly seen are spongiform degeneration of neurons, neuronal loss, gliosis, and amyloid plaque formation, accompanied by rapidly progressive dementia, myoclonus, motor disturbances, and encephalographic changes, with death occurring usually within a year of onset. Crigler-Najjar disease see under syndrome. Crohn's disease regional enteritis; a chronic granulomatous inflammatory disease usually in the terminal ileum with scarring and thickening of the wall, often leading to intestinal obstruction and formation of fistulas and abscesses. Crouzon's disease craniofacial dysostosis. Cruveilhier's disease spinal muscular atrophy. Cushing's disease Cushing's syndrome in which the hyperadrenocorticism is secondary to excessive pituitary secretion of adrenocorticotropic hormone. cystic disease of breast mammary dysplasia with formation of blue dome cysts. cytomegalic inclusion disease , cytomegalovirus disease an infection due to cytomegalovirus and marked by nuclear inclusion bodies in enlarged infected cells. In the congenital form, there is hepatosplenomegaly with cirrhosis, and microcephaly with mental or motor retardation. Acquired disease may cause a clinical state similar to infectious mononucleosis. When acquired by blood transfusion, postperfusion syndrome results. deficiency disease a condition caused by dietary or metabolic deficiency, including all diseases due to an insufficient supply of essential nutrients. degenerative joint disease osteoarthritis. Dejerine's disease , Dejerine-Sottas disease progressive hypertrophic neuropathy. demyelinating disease any condition characterized by destruction of the myelin sheaths of nerves. disappearing bone disease gradual resorption of a bone or group of bones, sometimes associated with multiple hemangiomas, usually in children or young adults and following trauma. diverticular disease a general term including the prediverticular state, diverticulosis, and diverticulitis. Duchenne's disease 1. spinal muscular atrophy. 2. progressive bulbar paralysis. 3. tabes dorsalis. 4. Duchenne's muscular dystrophy. Duchenne-Aran disease spinal muscular atrophy. Duhring's disease dermatitis herpetiformis. Dukes' disease a febrile disease of childhood marked by an exanthematous eruption, probably due to a virus of the Coxsackie-ECHO group. Durand-Nicolas-Favre disease lymphogranuloma venereum. Duroziez's disease congenital mitral stenosis. Ebola virus disease fatal acute hemorrhagic fever resembling Marburg virus disease but caused by Ebola virus, seen in the Sudan and Zaire. Ebstein's disease see under anomaly. end-stage renal disease chronic irreversible renal failure. Erb's disease Duchenne's muscular dystrophy. Erb-Goldflam disease myasthenia gravis. Eulenburg's disease paramyotonia congenita. extrapyramidal disease any of a group of clinical disorders marked by abnormal involuntary movements, alterations in muscle tone, and postural disturbances; they include parkinsonism, chorea, athetosis, etc. Fabry's disease an X-linked lysosomal storage disease of glycosphingolipid catabolism resulting from deficiency of α-galactosidase A and leading to accumulation of ceramide trihexoside in the cardiovascular and renal systems. Farber's disease a lysosomal storage disease due to defective ceramidase and characterized by hoarseness, aphonia, dermatitis, bone and joint deformities, granulomatous reaction, and psychomotor retardation. Fazio-Londe disease a rare type of progressive bulbar palsy occurring in childhood. Feer disease acrodynia. fibrocystic disease of breast a form of mammary dysplasia with formation of cysts of various size containing a semitransparent, turbid fluid that imparts a brown to blue color to the unopened cysts; believed due to abnormal hyperplasia of the ductal epithelium and dilatation of the ducts of the mammary gland, resulting from exaggeration and distortion of normal menstrual cycleâ??related breast changes. fibrocystic disease of the pancreas cystic fibrosis. fifth disease erythema infectiosum. flint disease chalicosis. floating beta disease familial dysbetalipoproteinemia. focal disease a localized disease. foot-and-mouth disease an acute, contagious viral disease of wild and domestic cloven-footed animals and occasionally humans, marked by vesicular eruption on the lips, buccal cavity, pharynx, legs, and feet. Forbes' disease glycogen storage d., type III. fourth disease Dukes' d. fourth venereal disease granuloma inguinale. Fox-Fordyce disease a persistent and recalcitrant, itchy, papular eruption, chiefly of the axillae and pubes, due to inflammation of apocrine sweat glands. Freiberg's disease osteochondrosis of the head of the second metatarsal bone. Friedländer's disease endarteritis obliterans. Friedreich's disease paramyoclonus multiplex. functional disease see under disorder. Garré's disease sclerosing nonsuppurative osteomyelitis. gastroesophageal reflux disease (GERD) any condition resulting from gastroesophageal reflux, characterized by heartburn and regurgitation; see also reflux esophagitis. Gaucher's disease a hereditary disorder of glucocerebroside metabolism, marked by the presence of Gaucher's cells in the marrow, and by hepatosplenomegaly and erosion of the cortices of long bones and pelvis. The adult form is associated with moderate anemia and thrombocytopenia, and yellowish pigmentation of the skin; in the infantile form there is, in addition, marked central nervous system impairment; in the juvenile form there are rapidly progressive systemic manifestations but moderate central nervous system involvement. genetic disease a general term for any disorder caused by a genetic mechanism, comprising chromosome aberrations (or anomalies), mendelian (or monogenic or single-gene) disorders, and multifactorial disorders. gestational trophoblastic disease see under neoplasia. Gilbert disease a familial, benign elevation of bilirubin levels without evidence of liver damage or hematologic abnormalities. Gilles de la Tourette's disease see under syndrome. Glanzmann disease see thrombasthenia. glycogen storage disease any of a number of rare inborn errors of metabolism caused by defects in specific enzymes or transporters involved in the metabolism of glycogen. type I glucose-6-phosphatase deficiency: a severe hepatorenal form due to deficiency of the hepatic enzyme glucose-6-phosphatase, resulting in liver and kidney involvement, with hepatomegaly, hypoglycemia, hyperuricemia, and gout type IA glycogen storage d., type I. type IB a form resembling type I but additionally predisposing to infection due to neutropenia and to chronic inflammatory bowel disease; due to a defect in the transport system for glucose 6-phosphate. type II a disorder due to deficiency of the lysosomal enzyme α-1,4,-glucosidase, the severe infant form resulting in generalized glycogen accumulation, with cardiomegaly, cardiorespiratory failure, and death, and a milder adult form being a gradual skeletal myopathy that sometimes causes respiratory problems. type III a form due to deficiency of debrancher enzyme (amylo-1,6-glucosidase) in muscle, liver, or both; defects in the liver enzyme are characterized by hepatomegaly and hypoglycemia while defects in the muscle enzyme are characterized by progressive muscle wasting and weakness. type IV brancher enzyme deficiency; cirrhosis of the liver, hepatosplenomegaly, progressive hepatic failure, and death due to deficiency of the glycogen brancher enzyme (1,4-α-glucan branching enzyme). type V muscle cramps and fatigue during exercise due to a defect in the skeletal muscle isozyme of glycogen phosphorylase (muscle phosphorylase). type VI hepatomegaly, mild to moderate hypoglycemia and mild ketosis, due to deficiency of the liver isozyme of glycogen phosphorylase (hepatic phosphorylase). type VII muscle weakness and cramping after exercise due to deficiency of the muscle isozyme of 6-phosphofructokinase. type VIII phosphorylase . graft-versus-host (GVH) disease disease caused by the immune response of histoincompatible, immunocompetent donor cells against the tissue of immunocompromised host, as a complication of bone marrow transplantation, or as a result of maternal-fetal blood transfusion, or therapeutic transfusion to an immunocompromised recipient. Graves' disease an association of hyperthyroidism, goiter, and exophthalmos, with accelerated pulse rate, profuse sweating, nervous symptoms, psychic disturbances, emaciation, and elevated basal metabolism. Greenfield's disease former name for the late infantile form of metachromatic leukodystrophy. Gull's disease atrophy of the thyroid gland with myxedema. Günther disease congenital erythropoietic porphyria. H disease Hartnup d. Hailey-Hailey disease benign familial pemphigus. Hallervorden-Spatz disease an autosomal recessive disorder caused by decreased numbers of myelin sheaths of the globus pallidus and substantia nigra, with accumulation of iron pigment, progressive rigidity beginning in the legs, choreoathetoid movements, dysarthria, and mental deterioration. Hand's disease Hand-Schüller-Christian d. hand-foot-and-mouth disease a mild, highly infectious viral disease of children, with vesicular lesions in the mouth and on the hands and feet. Hand-Schüller-Christian disease a chronic, progressive form of multifocal Langerhans cell histiocytosis, sometimes with accumulation of cholesterol, characterized by the triad of calvarial bone defects, exophthalmos, and diabetes insipidus. Hansen's disease leprosy. Hartnup disease a hereditary disorder of intestinal and renal transport of neutral α-amino acids, marked by a pellagra-like skin rash, with transient cerebellar ataxia, constant renal aminoaciduria, and other biochemical abnormalities. Hashimoto's disease a progressive disease of the thyroid gland with degeneration of its epithelial elements and replacement by lymphoid and fibrous tissue. heavy chain diseases a group of malignant neoplasms of lymphoplasmacytic cells marked by the presence of immunoglobulin heavy chains or heavy chain fragments; they are classified according to heavy chain type, e.g., alpha chain disease. Heine-Medin disease the major form of poliomyelitis. hemoglobin disease any of various hereditary molecular diseases characterized by abnormal hemoglobins in the red blood cells; the homozygous form is manifested by hemolytic anemia. hemolytic disease of the newborn erythroblastosis fetalis. hemorrhagic disease of the newborn a self-limited hemorrhagic disorder of the first few days of life, due to deficiency of vitamin Kâ??dependent coagulation factors II, VII, IX, and X. Hers' disease glycogen storage d., type VI. Heubner-Herter disease the infantile form of celiac disease. hip-joint disease tuberculosis of the hip joint. Hippel's disease von Hippel's d. Hirschsprung's disease congenital megacolon. His disease , His-Werner disease trench fever. Hodgkin's disease a form of malignant lymphoma marked clinically by painless, progressive enlargement of lymph nodes, spleen, and general lymphoid tissue; other symptoms may include anorexia, lassitude, weight loss, fever, pruritus, night sweats, and anemia. Reed-Sternberg cells are characteristically present. Four types have been distinguished on the basis of histopathologic criteria. hoof-and-mouth disease foot-and-mouth d. hookworm disease infection with the hookworm Ancylostoma duodenale or Necator americanus, whose larvae enter the body through the skin or in contaminated food or water and migrate to the small intestine where, as adults, they attach to the mucosa and ingest blood; symptoms may include abdominal pain, diarrhea, colic or nausea, and anemia. hyaline membrane disease a type of respiratory distress syndrome of the newborn in which there is formation of a hyaline-like membrane lining the terminal respiratory passages; extensive atelectasis is attributed to lack of surfactant. hydatid disease an infection, usually of the liver, due to larval forms of tapeworms of the genus Echinococcus, marked by development of expanding cysts. hypophosphatemic bone disease an inherited disorder resembling a mild form of X-linked hypophosphatemia, similarly due to a defect in renal tubular function but usually showing osteomalacia without radiographic evidence of rickets. immune complex disease local or systemic disease caused by the formation of circulating immune complexes and their deposition in tissue, due to activation of complement and to recruitment and activation of leukocytes in type III hypersensitivity reactions. infectious disease one due to organisms ranging in size from viruses to parasitic worms; it may be contagious in origin, result from nosocomial organisms, or be due to endogenous microflora from the nose and throat, skin, or bowel. inflammatory bowel disease any idiopathic inflammatory disease of the bowel, such as Crohn's disease and ulcerative colitis. intercurrent disease one occurring during the course of another disease with which it has no connection. iron storage disease hemochromatosis. ischemic bowel disease ischemic colitis. ischemic heart disease (IHD) any of a group of acute or chronic cardiac disabilities resulting from insufficient supply of oxygenated blood to the heart. Janský-Bielschowsky disease the late infantile form of neuronal ceroid lipofuscinosis, occurring between two and four years of age, characterized by abnormal accumulation of lipofuscin; beginning as myoclonic seizures and progressing to neurologic and retinal deterioration and death by age 8 to 12. jumping disease any of several culture-specific disorders characterized by exaggerated responses to small stimuli, muscle tics including jumping, obedience even to dangerous suggestions, and sometimes coprolalia or echolalia. juvenile Paget disease hyperostosis corticalis deformans juvenilis. Kashin-Bek (Kaschin-Beck) disease a disabling degenerative disease of the peripheral joints and spine, endemic in northeastern Asia; believed to be caused by ingestion of cereal grains infected with the fungus Fusarium sporotrichiella. Katayama disease schistosomiasis japonica. Kawasaki disease a febrile illness usually affecting infants and young children, with conjunctival injection, changes to the oropharyngeal mucosa, changes to the peripheral extremities including edema, erythema, and desquamation, a primarily truncal polymorphous exanthem, and cervical lymphadenopathy. It is often associated with vasculitis of the large coronary vessels. Kienböck's disease slowly progressive osteochondrosis of the lunate bone; it may affect other wrist bones. kinky hair disease Menkes' syndrome. Köhler's bone disease 1. osteochondrosis of the tarsal navicular bone in children. 2. thickening of the shaft of the second metatarsal bone and changes about its articular head, with pain in the second metatarsophalangeal joint on walking or standing. Krabbe's disease a lysosomal storage disease beginning in infancy, due to deficiency of β-galactosidase. Pathologically, there is rapidly progressive cerebral demyelination and large globoid bodies (swollen with accumulated cerebroside) in the white substance. Kufs' disease the adult form of neuronal ceroid lipofuscinosis, with onset prior to age 40; characterized by progressive neurologic deterioration but not blindness, excessive storage of lipofuscin, and shortened life expectancy; Kümmell's disease compression fracture of vertebra, with symptoms a few weeks after injury, including spinal pain, intercostal neuralgia, lower limb motor disturbances, and kyphosis. Kyasanur Forest disease a fatal viral disease of monkeys in the Kyasanur Forest of India, communicable to humans, in whom it produces hemorrhagic symptoms. Kyrle's disease a chronic disorder of keratinization marked by keratotic plugs that develop in hair follicles and eccrine ducts, penetrating the epidermis and extending down into the corium, causing foreign-body reaction and pain. Lafora's disease see under epilepsy. Leber's disease 1. Leber's hereditary optic neuropathy. 2. Leber's congenital amaurosis. legionnaires' disease an often fatal bacterial infection caused by Legionella pneumophila, not spread by person-to-person contact, characterized by high fever, gastrointestinal pain, headache, and pneumonia; there may also be involvement of the kidneys, liver, and nervous system. Leiner's disease a disorder of infancy characterized by generalized seborrhea-like dermatitis and erythroderma, severe intractable diarrhea, recurrent infections, and failure to thrive. Leriche disease post-traumatic osteoporosis. Letterer-Siwe disease a Langerhans cell histiocytosis of early childhood, of autosomal recessive inheritance, characterized by cutaneous lesions resembling seborrheic dermatitis, hemorrhagic tendency, hepatosplenomegaly, lymphadenitis, and progressive anemia. If untreated it is rapidly fatal. Called also acute disseminated Langerhans cell histiocytosis. Libman-Sacks disease see under endocarditis. Lindau's disease , Lindau-von Hippel disease von Hippel-Lindau d. Little's disease congenital spastic stiffness of the limbs, a form of cerebral palsy due to lack of development of the pyramidal tracts. Lobstein's disease see osteogenesis imperfecta. Lou Gehrig disease amyotrophic lateral sclerosis. Lowe disease oculocerebrorenal syndrome. Lutz-Splendore-Almeida disease paracoccidioidomycosis. Lyme disease a recurrent multisystemic disorder caused by the spirochete Borrelia burgdorferi, the vectors being the ticks Ixodes scapularis and I. pacificus; usually initially characterized by lesions of erythema chronicum migrans, followed by various manifestations including arthritis of the large joints, myalgia, and neurologic and cardiac abnormalities. lysosomal storage disease an inborn error of metabolism with (1) a defect in a specific lysosomal enzyme; (2) intracellular accumulation of an unmetabolized substrate; (3) clinical progression affecting multiple tissues or organs; (4) considerable phenotypic variation within a disease. MAC disease complex d. McArdle disease glycogen storage d., type V. mad cow disease bovine spongiform encephalopathy. Madelung's disease 1. see under deformity. 2. see under neck. maple bark disease hypersensitivity pneumonitis in logging and sawmill workers due to inhalation of spores of a mold, Cryptostroma corticale, growing under the maple bark. maple syrup urine disease (MSUD) a hereditary enzyme defect in metabolism of branched chain amino acids, marked clinically by mental and physical retardation, severe ketoacidosis, feeding difficulties, and a characteristic maple syrup odor in the urine and on the body. Marburg virus disease a severe, often fatal, viral hemorrhagic fever first reported in Marburg, Germany, among laboratory workers exposed to African green monkeys. Marchiafava-Micheli disease paroxysmal nocturnal hemoglobinuria. Marie-Bamberger disease hypertrophic pulmonary osteoarthropathy. Marie-Strümpell disease ankylosing spondylitis. Marie-Tooth disease Charcot-Marie-Tooth d. Mediterranean disease thalassemia major. medullary cystic disease familial juvenile nephronophthisis. Meniere's disease deafness, tinnitus, and dizziness, in association with nonsuppurative disease of the labyrinth. mental disease see under disorder. Merzbacher-Pelizaeus disease Pelizaeus-Merzbacher d. metabolic disease one caused by a disruption of a normal metabolic pathway because of a genetically determined enzyme defect. Meyer's disease adenoid vegetations of the pharynx. Mikulicz's disease benign, self-limited lymphocytic infiltration and enlargement of the lacrimal and salivary glands of uncertain etiology. Milroy disease hereditary permanent lymphedema of the legs due to lymphatic obstruction. Minamata disease a severe neurologic disorder due to alkyl mercury poisoning, with permanent neurologic and mental disabilities or death; once prevalent among those eating contaminated seafood from Minamata Bay, Japan. minimal change disease subtle alterations in kidney function demonstrable by clinical albuminuria and the presence of lipid droplets in cells of the proximal tubules, seen primarily in young children. mixed connective tissue disease a combination of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis, and marked serologically by the presence of antibody against extractable nuclear antigen. Möbius disease ophthalmoplegic migraine. molecular disease any disease in which the pathogenesis can be traced to a single molecule, usually a protein, which is either abnormal in structure or present in reduced amounts. Mondor's disease phlebitis affecting the large subcutaneous veins normally crossing the lateral chest wall and breast from the epigastric or hypochondriac region to the axilla. Monge's disease chronic mountain sickness. Morquio's disease , Morquio-Ullrich disease see under syndrome. motor neuron disease , motor system disease any disease of a motor neuron, including spinal muscular atrophy, progressive bulbar paralysis, amyotrophic lateral sclerosis, and lateral sclerosis. Mycobacterium avium complex disease MAC disease; systemic disease caused by infection with organisms of the Mycobacterium avium-intracellulare complex in patients with human immunodeficiency virus infection. Newcastle disease a viral disease of birds, including domestic fowl, transmissible to humans, characterized by respiratory, gastrointestinal or pulmonary, and encephalitic symptoms. new variant Creutzfeldt-Jakob disease (nvCJD) a variant of Creutzfeldt-Jakob disease having a younger age of onset than is seen in Creutzfeldt-Jakob disease, and caused by the same agent that causes bovine spongiform encephalopathy. Nicolas-Favre disease lymphogranuloma venereum. Niemann's disease , Niemann-Pick disease a lysosomal storage disease due to sphingomyelin accumulation in the reticuloendothelial system; there are five types distinguished by age of onset, amount of central nervous system involvement, and degree of enzyme deficiency. nil disease minimal change d. Norrie's disease an X-linked disorder consisting of bilateral blindness from retinal malformation, mental retardation, and deafness. notifiable disease one required to be reported to federal, state, or local health officials when diagnosed, because of infectiousness, severity, or frequency of occurrence. oasthouse urine disease methionine malabsorption syndrome. obstructive small airways disease chronic bronchitis with irreversible narrowing of the bronchioles and small bronchi with hypoxia and often hypercapnia. occupational disease disease due to various factors involved in one's employment. Oguchi's disease a form of hereditary night blindness and fundus discoloration following light adaptation. organic disease one associated with demonstrable change in a bodily organ or tissue. Osgood-Schlatter disease osteochondrosis of the tuberosity of the tibia. Osler's disease 1. polycythemia vera. 2. hereditary hemorrhagic telangiectasia. Owren's disease parahemophilia. Paget's disease 1. (of bone) osteitis deformans. 2. (of breast) an intraductal inflammatory carcinoma of the breast, involving the areola and nipple. 3. an extramammary counterpart of Paget's disease (2), usually involving the vulva, and sometimes other sites, as the perianal and axillary regions. Parkinson's disease a slowly progressive form of parkinsonism, usually seen late in life, marked by masklike facies, tremor of resting muscles, slowing of voluntary movements, festinating gait, peculiar posture, muscular weakness, and sometimes excessive sweating and feelings of heat. Parrot's disease see under pseudoparalysis. parrot disease psittacosis. Parry's disease Graves' d. Pelizaeus-Merzbacher disease a progressive familial form of leukoencephalopathy, marked by nystagmus, ataxia, tremor, parkinsonian facies, dysarthria, and mental deterioration. Pellegrini's disease , Pellegrini-Stieda disease calcification of the medial collateral ligament of the knee due to trauma. pelvic inflammatory disease (PID) any pelvic infection involving the upper female genital tract beyond the cervix. periodontal disease any disease or disorder of the periodontium. Perthes' disease osteochondrosis of capitular femoral epiphysis. Peyronie's disease induration of the corpora cavernosa of the penis, producing a painful fibrous chordee and penile curvature. Pfeiffer's disease infectious mononucleosis. Pick's disease 1. progressive atrophy of the cerebral convolutions in a limited area (lobe) of the brain, with clinical manifestations and course similar to Alzheimer's disease. 2. Niemann-Pick d. polycystic kidney disease , polycystic disease of kidneys either of two unrelated heritable disorders marked by cysts in both kidneys: the autosomal dominant or adult form is more common, appears in adult life, and is marked by loss of renal function that can be either rapid or slow; the autosomal recessive or infantile form is more rare, may be congenital or may appear later in childhood, and almost always progresses to renal failure. polycystic renal disease polycystic kidney d.. Pompe's disease glycogen storage d., type II. Pott's disease spinal tuberculosis. primary electrical disease serious ventricular tachycardia, and sometimes ventricular fibrillation, in the absence of recognizable structural heart disease. prion disease any of a group of fatal, transmissible neurodegenerative diseases, which may be sporadic, familial, or acquired, caused by abnormalities of prion protein metabolism resulting from mutations in the prion protein gene or from infection with pathogenic forms of the protein. pulseless disease Takayasu's arteritis. Raynaud's disease a primary or idiopathic vascular disorder, most often affecting women, marked by bilateral attacks of Raynaud's phenomenon. Recklinghausen's disease 1. neurofibromatosis. 2. (of bone) osteitis fibrosa cystica generalisata. Refsum's disease an inherited disorder of lipid metabolism, characterized by accumulation of phytanic acid, chronic polyneuritis, retinitis pigmentosa, cerebellar ataxia, and persistent elevation of protein in cerebrospinal fluid. remnant removal disease familial dysbetalipoproteinemia. reversible obstructive airway disease a condition characterized by bronchospasm reversible by intervention, as in asthma. rheumatic heart disease the most important manifestation and sequel to rheumatic fever, consisting chiefly of valvular deformities. rheumatoid disease a systemic condition best known by its articular involvement (rheumatoid arthritis) but emphasizing nonarticular changes, e.g., pulmonary interstitial fibrosis, pleural effusion, and lung nodules. Ritter's disease dermatitis exfoliativa neonatorum. Roger's disease a ventricular septal defect; the term is usually restricted to small, asymptomatic defects. runt disease a graft-versus-host disease produced by immunologically competent cells in a foreign host that is unable to reject them, resulting in gross retardation of host development and in death. Salla disease an inherited disorder of sialic acid metabolism characterized by accumulation of sialic acid in lysosomes and excretion in the urine, mental retardation, delayed motor development, and ataxia. Sandhoff's disease a type of GM2 gangliosidosis resembling Tay-Sachs disease, seen in non-Jews, marked by a progressively more rapid course, and due to a defect in hexosaminidase, both isozymes A and B. Schamberg's disease a slowly progressive purpuric and pigmentary disease of the skin affecting chiefly the shins, ankles, and dorsa of the feet. Schilder's disease subacute or chronic leukoencephalopathy in children and adolescents, similar to adrenoleukodystrophy; massive destruction of the white substance of the cerebral hemispheres leads to blindness, deafness, bilateral spasticity, and mental deterioration. Schönlein's disease see under purpura. secondary disease 1. one subsequent to or as a consequence of another disease. 2. one due to introduction of incompatible, immunologically competent cells into a host rendered incapable of rejecting them by heavy exposure to ionizing radiation. self-limited disease one that runs a limited and definite course. serum disease see under sickness. severe combined immunodeficiency disease (SCID) see under immunodeficiency . sexually transmitted disease venereal disease; any of a diverse group of infections transmitted by sexual contact; in some this is the only important mode of transmission, and in others transmission by nonsexual means is possible. sickle cell disease any disease associated with the presence of hemoglobin S. Simmonds' disease see panhypopituitarism. sixth disease exanthema subitum. small airways disease chronic obstructive bronchitis with irreversible narrowing of the bronchioles and small bronchi. See also obstructive small airways d. Smith-Strang disease methionine malabsorption syndrome. Spielmeyer-Vogt disease Vogt-Spielmeyer d. Steinert's disease myotonic dystrophy. Still's disease juvenile rheumatoid arthritis. storage disease a metabolic disorder in which a specific substance (a lipid, a protein, etc.) accumulates in certain cells in unusually large amounts. storage pool disease a blood coagulation disorder due to failure of the platelets to release adenosine diphosphate (ADP) in response to aggregating agents; characterized by mild bleeding episodes, prolonged bleeding time, and reduced aggregation response to collagen or thrombin. Strümpell's disease 1. hereditary lateral sclerosis with the spasticity mainly limited to the legs. 2. cerebral poliomyelitis. Strümpell-Leichtenstern disease hemorrhagic encephalitis. Strümpell-Marie disease ankylosing spondylitis. Sutton's disease 1. halo nevus. 2. periadenitis mucosa necrotica recurrens. 3. granuloma fissuratum. Swift's disease , Swift-Feer disease acrodynia. Takayasu's disease see under arteritis . Tangier disease a familial disorder characterized by a deficiency of high-density lipoproteins in the blood serum, with storage of cholesteryl esters in tissues. Tarui's disease glycogen storage d., type VII. Tay-Sachs disease (TSD) the most common GM2 gangliosidosis, seen almost exclusively in northeastern European Jews, characterized by infantile onset, doll-like facies, cherry-red macular spot, early blindness, hyperacusis, macrocephaly, seizures, hypotonia, and death in early childhood. Thomsen's disease myotonia congenita. thyrotoxic heart disease heart disease associated with hyperthyroidism, marked by atrial fibrillation, cardiac enlargement, and congestive heart failure. transmissible neurodegenerative disease prion d.. trophoblastic disease gestational trophoblastic neoplasia. tsutsugamushi disease scrub typhus. tunnel disease decompression sickness. uremic bone disease renal osteodystrophy. venereal disease sexually transmitted d. venoocclusive disease of the liver symptomatic occlusion of the small hepatic venules caused by ingestion of Senecio tea or related substances, by certain chemotherapy agents, or by radiation. vinyl chloride disease acro-osteolysis resulting from exposure to vinyl chloride, characterized by Raynaud's phenomenon and skin and bony changes on the limbs. Vogt-Spielmeyer disease the juvenile form of neuronal ceroid lipofuscinosis with onset between ages 5 and 10 years; characterized by rapid cerebroretinal degeneration, excessive neuronal storage of lipofuscin, and death within 10 to15 years. Volkmann's disease congenital deformity of the foot due to tibiotarsal dislocation. von Hippel's disease hemangiomatosis confined principally to the retina; when associated with hemangioblastoma of the cerebellum, it is known as von Hippel-Lindau d. von Hippel-Lindau disease a hereditary condition marked by hemangiomas of the retina and hemangioblastomas of the cerebellum, sometimes with similar lesions of the spinal cord and cysts of the viscera; there may be neurologic symptoms such as seizures and mental retardation. von Willebrand's disease an autosomal dominant bleeding disorder characterized by prolonged bleeding time, deficiency of von Willebrand's factor, and often impairment of adhesion of platelets on glass beads, associated with epistaxis and increased bleeding after trauma or surgery, menorrhagia, and postpartum bleeding. Waldenström's disease osteochondrosis of the capitular femoral epiphysis. Weber-Christian disease nodular nonsuppurative panniculitis. Werlhof's disease idiopathic thrombocytopenic purpura. Wernicke's disease see under encephalopathy. Westphal-Strümpell disease hepatolenticular degeneration. Whipple's disease a malabsorption syndrome marked by diarrhea, steatorrhea, skin pigmentation, arthralgia and arthritis, lymphadenopathy, central nervous system lesions, and infiltration of the intestinal mucosa with macrophages containing PAS-positive material. Whitmore's disease melioidosis. Wilson's disease an inherited, progressive disorder of copper metabolism, with accumulation of copper in liver, brain, kidney, cornea, and other tissues; it is characterized by cirrhosis in the liver, degenerative changes in the brain, and a pigmented ring at the outer margin of the cornea. Wolman's disease a lysosomal storage disease due to deficiency of the lysosomal sterol esterase, occurring in infants, and associated with hepatosplenomegaly, adrenal steatorrhea, calcification, abdominal distention, anemia, and inanition. woolsorter's disease inhalational anthrax. Dorland's Medical Dictionary for Health Consumers. © 2007 by Saunders, an imprint of Elsevier, Inc. All rights reserved. dis·ease (d-zz) n. A pathological condition of a body part, an organ, or a system resulting from various causes, such as infection, genetic defect, or environmental stress, and characterized by an identifiable group of signs or symptoms. The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved. disease Etymology: L, dis + Fr, aise, ease 1 a condition of abnormal vital function involving any structure, part, or system of an organism. 2 a specific illness or disorder characterized by a recognizable set of signs and symptoms attributable to heredity, infection, diet, or environment. Compare condition, diathesis. Mosby's Medical Dictionary, 8th edition. © 2009, Elsevier. disease, n abnormal functioning within an organism often expressed by specific bodily symptoms. This term is more concrete than illness, which includes mental aspects as well. disease affinity, n a homeopathic remedy's association with a certain illness or symptom. disease entities, n.pl term used for illnesses to emphasize the concept that sickness is separate from the person suffering from it. disease picture, n depiction of all disease-related symptoms in an individual. disease process, n progression of the illness, both mental and physical symptoms involved. disease(s), autoimmune (·tÅ?Ë?·im·yÅ?Å?nË? d·zÄ?zË?), n.pl conditions caused by immune system dysfunction that results in cells and antibodies attacking one's own tissue. disease, Adams-Stokes, n.pr disease marked by symptoms such as unanticipated and repeated black-out periods, and occasionally seizures due to an incomplete heart block. disease, Addison's, n.pr condition in which the adrenal glands are compromised because of infection, autoimmunity, hemorrhage, or neoplasm. Symptoms include anorexia, skin bronzing, dehydration, and gastrointestinal disturbances, among others. Life-threatening form requires meticulous medical and self care. Enlarge picture Disease, Addison's disease, Akureyi, n.pr condition marked by extreme and incapacitating fatigue, the cause of which is unknown. Accompanying symptoms can include pain as well as loss of sleep, concentration, and memory. disease, Albers-Schonberg, n.pr osteopetrosis form in which bones display calcification that resemble marbles. disease, Alexander's, n.pr variant of leukodystrophy characterized by an abnormal increase in brain size. disease, Alzheimer's, n.pr brain disease in which the individual gradually loses mental acuity and may become helpless. Characterized by protein deposits and abnormal tissue growth in the cerebral cortex. Enlarge picture Disease, Alzheimer's disease, Anderson's, n.pr rare, fatal disease characterized by abnormal glycogen deposits in tissues caused by deficiency of the branching enzyme (alpha-1:4, alpha1:6 transglucosidase). Not detectable at birth, infants eventually develop liver cirrhosis or heart failure. disease, celiac (sÄ?Ë?·lÄ?·ak d·zÄ?zË?), n metabolic disorder present at birth marked by the inability to hydrolyze the peptides found in gluten. Dietary changes can ensure full recovery. Also called celiac sprue, gluten-induced enteropathy, and nontropical sprue. Enlarge picture Disease, celiac. disease, chronic obstructive airway, n a progressive lung disorder, caused by blockage of the airways, which inhibits the breathing process; includes chronic bronchitis, chronic obstructive bronchitis, or emphysema, or combinations of these conditions. Enlarge picture Disease, chronic obstructive airway. disease, coronary heart, n a condition resulting from poor blood supply to the heart attributable to narrowing of the coronary arteries caused by accumulation of plaque, which ultimately leads to deterioration of heart function. Also called coronary artery disease. disease, Crohn's, n colon disease of unknown origin causing chronic inflammation, discomfort, frequent diarrhea, fever, nausea, abdominal pain, and weight loss. Also called regional enteritis. Enlarge picture Disease, Crohn's. disease, Crouzon's, n hereditary illness characterized by malformed skull as well as ocular problems including divergent squint, exophthalmos, and optic atrophy. Enlarge picture Disease, Crouzon's. disease, degenerative joint, n a medical condition that mostly affects the elderly and is marked by erosion of the joints, cartilage loss, and changes in the subchondral bone. Symptoms include tenderness, swelling, stiffness, worsening pain after use of a particular joint and the decreased functionality of a joint. Several nutritional supplements, vitamins, drugs, botanical medicines, balanced diet, and exercise are used to lessen the symptoms. Also called osteoarthritis or OA. disease, drug, n 1. condition caused by the lengthy use of a medication. 2. collection of symptoms experienced following a homeopathic treatment. disease, fibrocystic breast (FBD) (fÄ«Ë?·brÅ?·sisË?·tik brestË? di·zÄ?zË?), n common condition in premenopausal women characterized by the development of cysts of varying sizes in both breasts and the appearance of a nodular texture in the breasts. Symptoms include cydical tenderness and pain in the breast. Also called cystic mastitis. Enlarge picture Disease, fibrocystic breast. disease, gastroesophageal reflux (gasË?·trÅ?··sä·f·jÄ?Ë?·l rÄ?Ë?·flks di·zÄ?zË?), n condition in which the acidic contents of the stomach reflux up into the esophagus. Symptoms include heartburn, regurgitation, and pulmonary irregularities. May cause damage to the esophageal tissues. Causes may include hiatal hernia, alcohol, overeating, smoking, fatty foods, and caffeine. Also called acid reflux, reflux, or reflux esophagitis. disease, heart, n any disorder that affects the heart's function. disease, iatrogenic, n disorders caused by medical intervention or through exposure to healthcare facilities. disease, Lou Gehrig's, n See amyotrophic lateral sclerosis. disease, mixed connective tissue, n a systemic disease distinguished by a combination of symptoms that are present in a variety of rheumatic diseases like polymyositis, systemic lupus erythematosus, and scleroderma. Presence of antinuclear antibodies, muscle inflammation, swollen hands, nondeforming arthritis, and arthralgia are some indications. Corticosteroids are commonly prescribed for treatment. Enlarge picture Disease, mixed connective tissue. disease, Parkinson's, n.pr neuro-logical disorder characterized by progressive degeneration of neurons producing dopamine. Symptoms inlcude tremors, movement difficulties, speech impediment and often dementia. Enlarge picture Disease, Parkinson's. disease, pelvic inflammatory, n inflammation and infections affecting the pelvic region. Pain in the lower abdomen, tenderness in the adnexal region to palpitation and sensitivity to touch in the cervical region after movement are common symptoms. Enlarge picture Disease, pelvic inflammatory (PID). disease, peptic ulcer, n ailment in which a sharply defined area or areas in the gastrointestinal mucous membranes deteriorate. Occurs most commonly in the stomach and duodenum. Enlarge picture Disease, peptic ulcer. disease, periodontal, n inflammatory condition affecting the periodon-tium or gingival regions, progressing from gingivitis to periodontitis. It can be a manifestation of an underly-ing medical condition including leukemia, diabetes mellitus, vitamin deficiency, or anemia. disease, psychosomatic, n any condition in which detrimental physio-logical changes are facilitated by psychological and affective stressors. disease, somatopsychic (sÅ?·maË?·t·sÄ«Ë?·kik di·zÄ?zË?), n any condition in which detrimental psychological changes are facilitated by physical and physiological stressors. Jonas: Mosby's Dictionary of Complementary and Alternative Medicine. (c) 2005, Elsevier. disease(s) (dizÄ?z´), n a definite deviation from the normal state characterized by a series of symptoms. Disease may be caused by developmental disturbances, genetic factors, metabolic factors, living agents, or physical, chemical, or radiant energy, or the cause may be unknown. disease, Adams-Stokes (Adams-Stokes syndrome), n.pr a disease characterized by a slow and perhaps irregular pulse, vertigo, syncope, occasional pseudoepileptic convulsions, and Cheyne-Stokes respirations. disease, adaptation (adaptation syndrome), n the metabolic disorders occurring as a result of adaptation or resistance to severe physical or psychologic stress. See also syndrome, general adaptation. disease, Addison's, n.pr a chronic adrenocortical insufficiency caused by bilateral tuberculosis, aplasia, atrophy, or degeneration of the adrenal glands. Symptoms include severe weakness, weight loss, low blood pressure, digestive disturbances, hypoglycemia, lowered resistance to infection, and abnormal pigmentation (bronze color of the skin, with associated melanotic pigmentation of the oral mucosa, especially of the gingival tissues). disease, adrenocortical, n the disorders of adrenocortical function, giving rise to Addison's disease, Cushing's syndrome, adrenogenital syndrome, and primary aldosteronism. disease, Albers-Schönberg, n.pr See osteopetrosis. disease, autoallergic, n See disease, autoimmune. disease, autoimmune (autoallergic disease, autoimmunization syndrome, chronic hypersensitivity), n a disease that is believed to be caused in part by reactions of hypersensitivity of the host tissue (antigens). Includes various hemolytic anemias, idiopathic thrombocytopenias, rheumatoid arthritis, systemic lupus erythematosus, glomerulonephritis, scleroderma, Hashimoto's thyroiditis, and Sjögren's syndrome. disease, Barlow's, n.pr See scurvy, infantile. disease, Basedow's, n.pr See goiter, exophthalmic. disease, Behçet's, n.pr See syndrome, Behçet's. disease, Besnier-Boeck-Schaumann, n.pr See sarcoidosis. disease, bleeder's, n See hemophilia. disease, blood, n a disease affecting the hematologic system (e.g., anemia, leukemia, agranulocytosis purpura, infectious mononucleosis). Such a disease often results in lesions of the oral structures, particularly the mucosal surfaces. disease, Bowen's, n.pr See carcinoma in situ. disease, Brill-Symmers, n.pr See lymphoblastoma, giant follicular. disease, brittle bone, n See osteogenesis imperfecta. disease, Caffey's, n.pr See hyperostosis, infantile cortical. disease, Cannon's, n.pr See nevus, white sponge. disease, cardiac, n a disease affecting the heart. disease, cat-scratch, n a granulomatous disease caused by B. henselae that occurs at the site of a scratch or bite of a house cat. Local lesions occur at the site of injury with a regional adenitis that is out of proportion to the primary lesion occurring within 1 to 3 weeks. Systemic symptoms of infection may occur. Diagnosis is confirmed by serologic tests. Enlarge picture Cat-scratch disease. disease, celiac, n See celiac sprue. disease, Cheadle's, n.pr See scurvy, infantile. disease, Christmas, n.pr See hemophilia B. disease, chronic hypersensitivity, n See disease, autoimmune. disease, chronic obstructive pulmonary (COPD), n a disease marked by decreased expiratory flow rates resulting in increased total lung capacity. Patients with this condition are prone to acute respiratory failure from infections or general anesthesia. disease, collagen (group disease, visceral angiitis) (kol´jin), n a group of diseases affecting the collagenous connective tissue of several organs and systems. These diseases have similar biochemical structural alterations and include rheumatic fever, scleroderma, rheumatoid arthritis, systemic lupus erythematosus, periarteritis, and serum sickness. diseases, communicable, n a disease that may be transmitted directly or indirectly to a well person or animal from an infected person or animal. A disease with the capacity for maintenance by natural modes of spread (e.g., by contact, by airborne routes, through drinking water or food, by arthropod vectors). disease, congenital, n a disease present at birth, or, more specifically, one that is acquired in utero. disease, Coxsackie A, n.pr See herpangina. disease, Crouzon, n.pr See syndrome, Crouzon. disease, Cushing's, n.pr hypercortisolism that results from an adrenal or pituitary neoplasm. The term Cushing's syndrome refers to hypercortisolism that is not related to an endogenous process. disease, cytomegalic inclusion, generalized, n See disease, salivary gland. disease, Darier's (keratosis follicularis), n.pr an apparently genetic dermatologic disease that also involves mucous membranes. The oral lesions are whitish papules of the gingiva, tongue, or palate. It is characterized histologically by the presence of corps ronds. disease, deficiency, n a disturbance produced by lack of nutritional or metabolic factors. Used mainly in reference to avitaminosis. disease, degenerative joint, n See osteoarthritis. disease, dermatologic, n a disease affecting the skin; often accompanied by pathologic manifestations of various mucosal surfaces (e.g., the oral mucosa, genital mucosa, conjunctiva). disease, end-stage, n the last phase of an illness, at which point the patient's life is gravely endangered. disease, Engman's, n.pr See dermatitis infectiosa eczematoides. disease, exanthematous n a group of diseases caused by a number of viruses but having as a prominent feature a skin rash (e.g., smallpox, chickenpox, cowpox, measles, rubella). disease, familial, n a disease occurring in several members of the same family. Often used to mean members of the same generation and occasionally used synonymously with hereditary disease. disease, Feer's, n.pr See erythredema polyneuropathy and acrodynia. disease, fibrocystic (mucoviscidosis) (fī´brÅ?sis´tik mū´kÅ?vis´idÅ?´sis), n a hereditary defect of most of the exocrine glands in the body, including the salivary glands. The secretion of the affected mucous glands is abnormally viscous. disease, fifth, n a viral infection caused by the human parvovirus B19; spread via the upper respiratory tract, this virus impacts on children more strongly than adults. Also called erythema infectiosum. disease, Fordyce's, n.pr See Fordyce granules. disease, functional, n a disease that has no observable or demonstrable cause. disease, Gaucher's (gôshÄ?z´), n.pr a constitutional defect in the metabolism of the cerebroside kerasin. This glycoprotein accumulates in the reticuloendothelial system and leads to splenomegaly, hepatomegaly, lymph node enlargement, and bone defects. disease, graft-versus-host (GVHD), n a potentially deadly condition resulting from allogenically transplanted hematopoietic cells that reject host cells in the transplant recipient. In early stages, this condition may result in lichenoid and erosive lesions on the oral mucosa. disease, Graves', n.pr See goiter, exophthalmic. disease, hand-foot-and-mouth (aphthous fever, epidemic stomatitis, epizootic stomatitis) (af´ths), n primarily a disease of animals caused by a filterable virus that may be transmitted to humans and that occasionally produces symptoms. The human form is characterized by fever, nausea, vomiting, malaise, and ulcerative stomatitis. Skin lesions consisting of vesicles may appear, usually on the palms of the hands and soles of the feet. Spontaneous regression usually occurs within 2 weeks. Enlarge picture Hand, foot, and mouth disease. disease, Hand-SchÅ«ller-Christian (chronic disseminated histiocytosis X), n.pr a type of cholesterol lipoidosis characterized clinically by defects in membranous bones, exophthalmos, and diabetes insipidus. disease, Hansen's, n.pr See leprosy. disease, heart, n an abnormal condition of the heart (organic, mechanical, or functional) that causes difficulty. disease, heart, arteriosclerotic, n a variety of functional changes of the myocardium that result from arteriosclerosis. disease, heart, congenital, n a defective formation of the heart or of the major vessels of the heart. disease, heart, ischemic (iskÄ?´mik), n a heart condition in which an inadequate supply of oxygenated blood reaches the heart, resulting in damage to the heart muscle; it is usually caused by atherosclerosis, a buildup of fatty plaque deposits in the main coronary arteries that leads to narrowing or hardening of the arteries. Symptoms include chest pain or discomfort (angina pectoris), ventricular fibrillation, heart attack (myocardial infarction), or sudden death. Also known as coronary artery disease and coronary heart disease. disease, heart, rheumatic, n a scarring of the endocardium resulting from involvement in acute rheumatic fever. The process most often involves the mitral valve. disease, heart, thyrotoxic n cardiac failure occurring as the result of hyperthyroidism or its superimposition on existing organic heart disease. Thyrotoxicosis is an important cause of auricular fibrillation. disease, hemoglobin C, n a disease resulting from an abnormal hemoglobin (hemoglobin C); occurs primarily in African Americans and causes a mild normochromic anemia, target cells, and vague, intermittent arthralgia. disease, hemolytic, of newborn,
Atcha Member	Wed Oct 07 03:07:36 n a hemolysis caused by isoimmune reactions associated with Rh incompatibility or with blood transfusions in which there is an incompatibility of the ABO blood system. Several forms of the disease occur: erythroblastosis fetalis, congenital hemolytic disease, icterus gravis neonatorum, and hydrops fetalis. disease, hemophilioid n a hemophilic states (conditions) that clinically resemble hemophilia (e.g., parahemophila, hemophilia B [Christmas disease]). disease, hemorrhagic, of newborn (hem´raj´ik), n a hemorrhagic tendency in newborn infants occurring usually on the third or fourth day of life; believed to be caused by defects of prothrombin and factor VII, resulting from a deficiency of vitamin K. disease, hereditary, n a disease transmitted from parent to offspring through genes. Three main types of mendelian heredity are recognized: dominant, recessive, and sex-linked. disease, hidebound, n See scleroderma. disease, Hodgkin, n.pr See lymphoma, Hodgkin. disease, hypersensitivity, n See disease, autoimmune. disease, iatrogenic (Ä«at´rjen´ik), n a disease arising as a result of the actions or words of a health care professional. disease, idiopathic n a disease in which the etiology is not recognized or determined. disease, infectious, n the pathologic alterations induced in the tissues by the action of microorganisms and/or their toxins. Some infectious diseases involving the oral tissues are herpes zoster, herpetic gingivostomatitis, moniliasis, syphilis, and tuberculosis. disease, inflammatory neoplastic, n See granuloma; tumor, inflammatory. disease, kissing, n See mononucleosis, infectious. disease, Langerhans cell (Langerhans cell histiocytosis), n a group of three diseases identified by an abundance of Langerhans cellsâ??eosinophils combined with histiocytic cells. See also disease, Letterer-Siwe; disease, Hand-SchÅ«ller-Christian; and granuloma, eosinophili. disease, Letterer-Siwe n.pr (acute disseminated histiocytosis X, nonlipid histiocytosis, nonlipid reticuloendotheliosis), a fatal febrile disease of unknown cause occurring in infants and children; characterized by focal granulomatous lesions of the lymph nodes, spleen, and bone marrow. Results in enlargement of the lymph nodes, spleen, and liver, defects of the flat and long bones, anemia, and sometimes purpura. disease, lipoid storage (lipoidosis, reticuloendothelial granuloma) (lip´oid ritik´ylÅ?en´dÅ?thÄ?´lÄ?l gran´ylÅ?´m lipoidÅ?´sis), n group of diseases in which lipid substances accumulate in the fixed cells of the reticuloendothelial system. Included are Gaucher's disease, Niemann-Pick disease, and the Hand-SchÅ«ller-Christian disease complex. Other storage diseases include lipochondrodystrophy (gargoylism) and cerebral sphingolipidosis. disease, Lobstein's, n.pr See osteogenesis imperfecta. disease, macrovascular, n a disease of the large blood vessels, including the aorta, and coronary arteries. Fatty plaque buildup and thrombosis formation in these vessels may lead to a myocardial infarction, cerebral infarction, and circulation problems in the limbs. It is often a complication of long-term diabetes. disease, Marie's, n.pr See acromegaly. disease, Mediterranean, n.pr See thalassemia major. disease, metabolic bone, n.pl the diseases of the bone which may be attributed to cellular changes or to nutritional deficiencies/excesses brought on by dietary imbalances. These include hyperparathyroidism, osteoporosis, osteomalacia, rickets, and the many diseases associated with an abnormal abundance of Langerhans cells. disease, Mikulicz' (mik´ūlich´z), n.pr a benign hyperplasia of the lymph nodes of the parotid or other salivary glands and/or the lacrimal glands. disease, Moeller's, n.pr See scurvy, infantile. disease, molecule, n a disease associated with genetically determined abnormalities of protein synthesis at the molecular level. disease, muscle, n the pathologic muscle tissue changes that can lead to disease. Such changes reveal few structural alterations, and the highly differentiated contents of muscle fibers tend to react as a whole. The pathologic features that distinguish one muscle disease from another are the age and character of changes within a muscle, distribution of those changes within one or several muscles, presence of inflammatory cells and parasites, and coexistence of pathologic changes in other organs. Muscles undergo a number of degenerative changes. There are alterations in the striation in certain pathologic states caused by cloudy swelling, granular degeneration, waxy or hyaline degeneration, and other cellular modifications such as multiplication of the sarcolemmic nuclei and phagocytosis of muscle fibers. disease, neuromuscular, n a condition in which various areas of the central nervous system are affected; results in dysfunction or degeneration of the musculature and disabilities of the organ. disease, Niemann-Pick n.pr a congenital, familial disorder occurring mainly in Jewish female infants that terminates fatally before the third year and is characterized by the accumulation of the phospholipid sphingomyelin in the cells of the reticuloendothelial system. disease, oral, hereditary, n the heritable defects of oral and paraoral structures (excluding the dentition) without generalized defects; includes ankyloglossia, hereditary gingivofibromatosis, and possibly cleft lip and cleft palate. Many oral and paraoral defects are associated with generalized defects (e.g., Peutz-Jeghers, Franceschetti, Ehlers-Danlos, Pierre Robin, and Sturge-Weber syndromes; hemorrhagic telangiectasia; Crouzon's disease; sickle cell disease; acatalasemia; white spongy nevus; xeroderma pigmentosum; gargoylism; neurofibromatosis; familial amyloidosis; and achondroplasia). disease, oral manifestations of systemic, n the lesions in association with systemic disease, often influenced by the local environmental factors within the oral cavity. disease, organic, n a disease in which actual structural changes have occurred in the organs or tissues. disease, Osler's, n.pr See erythremia. disease, Owren's, n.pr See parahemophilia. disease, Paget's, of bone (osteitis deformans), n.pr a bone disease characterized by thickening and bowing of the long bones and enlargement of the skull and maxillae. It is represented radiographically by a cotton-wool appearance of the bone and microscopically by a mosaic bone pattern with so-called reversal lines. Hypercementosis and loosening of the teeth may be significant manifestations. Increased serum alkaline phosphatase may be an early finding. Enlarge picture Paget's disease of the bone. disease, Parkinson's, n.pr a progressive neurologic disorder for which there is no known cure that is thought to be the result of neuron degeneration in the section of the brain controlling spontaneous movement and balance. The disease causes postural changes, tremors, muscle rigidity, and weakness. Oral manifestations include difficulty in swallowing and excess salivation. disease, periodic, n See disorder(s), periodic. disease, periodontal n a disturbance of the periodontium. Diseases affecting the periodontium include aggressive and necrotizing types, as well as gingivitis. Etiologic factors may be local or systemic or may involve an interplay between the two. Periodontal diseases may be involved in increasing the risk and course of systemic diseases. disease, periodontal, etiologic factors of, n.pl the local and systemic factors, singly or in combination, that initiate periodontal lesions. disease, periodontal, local factors of, n.pl the environmental conditions within the oral cavity that initiate, enable, or alter the course of diseases of the periodontium (e.g., calculus, diastemata between teeth, food impaction, prematurities in the centric path of closure, and tongue habits). disease, peripheral vascular, n a disease of arteries, veins, and/or lymphatic vessels. disease, pink, n See acrodynia. disease, Pott's, n.pr a spinal curvature (kyphosis) resulting from tuberculosis. disease progression, n the course of the disease within a patient/host from onset to resolution. disease, psychosomatic (sī´kÅ?sÅ?mat´ik), n a disease that appears to have been precipitated or prolonged by emotional stress; manifested largely through the autonomic nervous system. Various conditions may be included (e.g., certain forms of asthma, dermatosis, migraine headache, and hypertension). See also disorder, psychophysiologic, autonomic, and visceral. disease, Quincke's, n.pr See edema, angioneurotic. disease, Rendu-Osler-Weber (ron´doo), n.pr See telangiectasia, hereditary hemorrhagic. disease, rheumatic, n See rheumatism. disease, rickettsial (riket´sÄ?l), n a disease caused by microorganisms of the order Rickettsiales (e.g., Rocky Mountain spotted fever, rickettsialpox, typhus, and Q fever). disease, Riga-Fede (rÄ?´g-fÄ?´d), an ulceration of the lingual frenum of infants caused by abrasion by natal or neonatal teeth. disease, Sainton's, n.pr See dysplasia, cleidocranial. disease, salivary gland (generalized cytomegalic inclusion), n a generalized infection in infants caused by intrauterine or postnatal infection with a cytomegalovirus of the group of herpesviruses. Manifestations include jaundice, purpura, hemolytic anemia, vomiting, diarrhea, chronic eczema, and failure to gain weight. disease, SchÅ«ller's n.pr See osteoporosis. disease, Selter's, n.pr See acrodynia. disease, sex-linked, n a hereditary disorder transmitted by the gene that also determines sex (e.g., hemophilia). disease, sickle cell, n a hematologic disorder caused by the presence of an abnormal hemoglobin (hemoglobin S) that permits the formation or results in the formation of sickle-shaped red blood cells. Two forms of the disease occur: sickle cell trait and sickle cell anemia. See also anemia, sickle cell; trait, sickle cell. disease, Simmonds' (pituitary cachexia, hypophyseal cachexia, hypopituitary cachexia), n.pr a panhypopituitarism resulting from destruction of the pituitary gland, usually from hemorrhage or infarction. disease, Sturge-Weber-Dimitri (encephalotrigeminal angiomatosis), n.pr See angiomatosis, Sturge-Weber. disease susceptibility, n the degree to which a patient or host is vulnerable to a disease. disease, Sutton's, n.pr See periadenitis mucosa necrotica recurrens. disease, Swift's, n.pr See acrodynia. disease, systemic, n a disease involving the whole body. disease, Takahara's n.pr a form of rare progressive oral gangrene occurring in childhood and seen only in Japan. Apparently related to a congenital lack of the enzyme catalase (acatalasemia). Characterized by a mild to severe form of a peculiar type of oral gangrene that may develop at the roots of the teeth or the tonsils. Loss of teeth occurs, with necrosis of the alveolar bone. Patients become symptom free after puberty. disease, transmissible, n a disease capable of being transmitted from one individual to another; a disease capable of being maintained in successive passages through a susceptible host, usually under experimental conditions such as by injection. See also disease, communicable. disease transmission, n the method by which a disease is passed from one patient or host to another. The three most common methods of transmission are direct contact, aerosols, and vectors, such as insects. disease, Vaquez' n.pr See erythremia. disease vectors, n.pl the intermediary hosts that carry the disease from one species to another, such as mosquitoes, ticks, and rabid animals. disease, von Recklinghausen's, n.pr See hyperparathyroidism; osteitis; generalized fibrosa cystica; and neurofibromatosis. disease, von Recklinghausen's, of bone (fÅ?n rek´linghouzenz), n.pr See hyperparathyroidism; osteitis fibrosa cystica. disease, von Recklinghausen's, of skin, n.pr See neurofibromatosis. disease, von Willebrand's (fÅ?n vil´ebränts), n.pr an inherited blood coagulation disorder attributed to a deficiency or malfunction of factor VIII. It may cause prolonged or excessive gingival bleeding. disease, Weil's (epidemic jaundice) n.pr an acute febrile disease caused by Leptospira icterohaemorrhagiae or L. canicola. Manifestations include fever, petechial hemorrhage, myalgia, renal insufficiency, hepatic failure, and jaundice. disease, Werlhof's (verl´hofs), n.pr See purpura, thrombocytopenic. diseases, demyelinating n the diseases that have in common a loss of myelin sheath, with preservation of the axis cylinders (e.g., multiple sclerosis, Schilder's disease). diseases, dental, hereditary, n.pl the heritable defects of the dentition without generalized disease, which include amelogenesis imperfecta, dentinogenesis imperfecta, dentinal dysplasia, localized and generalized hypoplasia of enamel, peg-shaped lateral incisors, familial dentigerous cysts, missing teeth, giantism, and fused primary mandibular incisors. Dental defects occurring with generalized disease include dentinogenesis imperfecta with osteogenesis imperfecta, missing teeth with ectodermal dysplasia, enamel hypoplasia with epidermolysis bullosa dystrophica, retarded eruption with cleidocranial dysostosis, missing lateral incisors with ptosis of the eyelids, missing premolars with premature whitening of the hair, and enamel hypoplasia in vitamin D resistant rickets. diseases, group, n See disease, collagen. Mosby's Dental Dictionary, 2nd edition. © 2008 Elsevier, Inc. All rights reserved. disease traditionally defined as a finite abnormality of structure or function with an identifiable pathological or clinicopathological basis, and with a recognizable syndrome or constellation of clinical signs. This definition has long since been widened to embrace subclinical diseases in which there is no tangible clinical syndrome but which are identifiable by chemical, hematological, biophysical, microbiological or immunological means. The definition is used even more widely to include failure to produce at expected levels in the presence of normal levels of nutritional supply and environmental quality. It is to be expected that the detection of residues of disqualifying chemicals in foods of animal origin will also come to be included within the scope of disease. For specific diseases see under the specific name, e.g. Aujeszsky's disease, Bang's disease, foot-and-mouth disease. air-borne disease the causative agent is transmitted via the air without the need for intervention by other medium. See also wind-borne disease. disease carrier see carrier, vector. clinical disease see clinical (3). disease cluster a group of animals with the same disease occurs at an unusual level of prevalence for the population as a whole. The cluster may be in space, with high concentrations in particular localities, or in time, with high concentrations in particular seasons or in particular years. communicable disease infectious disease in which the causative agents may pass or be carried from one animal to another directly or indirectly on inanimate objects or via vectors. complicating disease one that occurs in the course of some other disease as a complication. constitutional disease one involving a system of organs or one with widespread signs. contagious disease see communicable disease (above). disease control reducing the prevalence of a disease in a population, including eradication, by chemical, pharmaceutical, quarantine, management including culling, or other means or combinations of means. disease control programs organized routines specifying agents, administration, time and personnel allocations, community support, funding, participation of corporate or government agencies, animal and animal product disposal. deficiency disease a condition due to dietary or metabolic deficiency, including all diseases caused by an insufficient supply of essential nutrients. degenerative joint disease see degenerative joint disease, osteoarthritis. demyelinating disease any condition characterized by destruction of myelin. disease determinant any variable associated with a disease which, if removed or altered, results in a change in the incidence of the disease. egg-borne disease an infectious disease of birds in which the agent is spread via the egg. endemic disease see endemic. environmental disease control control by changing the environment, e.g. draining a swamp, ventilating a barn. epidemic disease see epidemic. etiological disease classification diseases arranged in the order of their etiological agents, e.g. bacterial, mycoplasma. exotic disease a disease that does not occur in the subject country. Said of infectious diseases that may be introduced, e.g. rabies is exotic to the UK, contagious bovine pleuropneumonia is exotic to the USA. focal disease a localized disease. fulminant disease an explosive outbreak in a group or a rapidly developing, peracute development of a disease in an individual. Called also fulminating. functional disease any disease involving body functions but not associated with detectable organic lesion or change. generalized disease one involving all or many body systems; often said of infectious diseases in which there is spread via the bloodstream. See also systemic disease (below). glycogen disease any of a group of genetically determined disorders of glycogen metabolism, marked by abnormal storage of glycogen in the body tissues. See also glycogen storage disease. heavy chain disease see heavy-chain disease. hemolytic disease of newborn see alloimmune hemolytic anemia of the newborn. hemorrhagic disease of newborn see neonatal hemorrhagic disease. disease history that part of a patient's history which relates only to the disease from which the patient is suffering. holoendemic disease most animals in the population are affected. hyperendemic disease the rate of infection is steady but high. hypoendemic disease the rate of infection is steady and only a few animals are infected. immune complex disease see immune complex disease. infectious disease one caused by small living organisms including viruses, bacteria, fungi, protozoa and metazoan parasites. It may be contagious in origin, result from nosocomial infections or be due to endogenous microflora of the nose and throat, skin or bowel. See also communicable disease (above). manifestational disease classification diseases arranged in the order of their clinical signs, epidemiological characteristics, necropsy lesions, e.g. sudden death diseases. mesoendemic disease the disease occurs at an even rate and a moderate proportion of animals are infected. metabolic disease see metabolic diseases. molecular disease any disease in which the pathogenesis can be traced to a single, precise chemical alteration, usually of a protein, which is either abnormal in structure or present in reduced amounts. The corresponding defect in the DNA coding for the protein may also be known. multicausal disease 1. a number of causative agents are needed to combine to cause the disease. 2. the same disease can be caused by a number of different agents. multifactorial disease see multicausal disease (above). new disease disease not previously recorded. May be variants on an existing disease, e.g. infectious bovine rhinotracheitis, or escapes from other species, e.g. the Marburg virus disease of humans. notifiable disease a disease of which any occurrence is required by law to be notified to government authorities. organic disease see organic disease. pandemic disease a very widespread epidemic involving several countries or an entire continent. quarantinable disease a disease which the law requires to be restricted in its spread by putting the affected animals, farms or properties on which it occurs in quarantine. reportable disease see notifiable disease (above). disease reservoir any animal or fomite in which an infectious disease agent is preserved in a viable state or multiplies and upon which it may depend for survival. secondary disease 1. a disease subsequent to or a consequence of another disease or condition. 2. a condition due to introduction of incompatible, immunologically competent cells into a host rendered incapable of rejecting them by heavy exposure to ionizing radiation. self-limited disease see self-limited. sex-limited disease disease limited in its occurrence to one or other sex. See also sex-linked. sexually transmitted disease (STD) a disease that can be acquired by sexual intercourse. slaughter disease control see slaughter (2). sporadic disease occurring singly and haphazardly; widely scattered; not epidemic or endemic. See also sporadic bovine encephalomyelitis, sporadic leukosis, sporadic lymphangitis. storage disease see storage disease. disease syndrome see syndrome. systemic disease sufficiently widespread in the body to cause clinical signs referable to any organ or system, and in which localization of infection may occur in any organ. disease triangle interaction between the host, the disease agent, and the environment. disease wastage loss of income generated by production of milk, eggs, fiber, or loss of capital value because of diminution in the patient's value. wasting disease any disease marked especially by progressive emaciation and weakness. zoonotic disease disease capable of spread from animals to humans. See also zoonosis. Saunders Comprehensive Veterinary Dictionary, 3 ed. © 2007 Elsevier, Inc. All rights reserved disease An abnormal process affecting the structure or function of a part, organ or system of the body. It is typically manifested by signs and symptoms, but the aetiology may or may not be known. Disease is a response to a specific infective agent (a microorganism or a poison), to environmental factors (e.g. malnutrition, injury, industrial hazards), to congenital or hereditary defects, or to a combination of all these factors. Note: illness is sometimes used as a synonym of disease, but it also refers to a person's perception of their health, regardless of whether the person does or does not have a disease. autoimmune disease A disease produced when the immune response of an individual is directed against its own cells or tissues. It is not yet known exactly what causes the body to react to one's own antigens as if they were foreign. Examples: diabetes mellitus type 1; Graves' disease; multiple sclerosis; myasthenia gravis; rheumatoid arthritis; Reiter's disease; Sjögren's syndrome. Batten-Mayou disease Juvenile form of amaurotic family idiocy. It is characterized by progressive degeneration of the retina, which eventually leads to blindness. Syn. Spielmeyer-Stock disease. Behçet's disease See Behçet's syndrome. Benson's disease See asteroid hyalosis. Berlin's disease A traumatic phenomenon in which the posterior pole of the retina develops oedema (and haemorrhages). Syn. commotio retinae. Best's disease An autosomal dominant inherited degeneration in which there is an accumulation of lipofuscin within the retinal pigment epithelium, which interferes with its function. It is caused by a mutation in bestrophin gene (BEST1). The disease is characterized by the appearance on the retina in the first and second decades of life of a bright orange deposit, resembling the yolk of an egg (vitelliform), with practically no effect on vision. It eventually absorbs, leaving scarring, pigmentary changes and impairment of central vision in most cases, although in some cases the retinal lesion may be eccentric, with very little effect on vision. The electrooculogram is abnormal throughout the development of the disease from pre-vitelliform, vitelliform and the end-stage when there is scarring or atrophy. Syn. Best's macular dystrophy; juvenile vitelliform macular dystrophy; vitelliform macular dystrophy. Mutation in the VMD2 gene can cause adult vitelliform macular dystrophy, a condition characterized by smaller macular lesions and very little impairment of vision. See pattern dystrophy. Bowen's disease A disease characterized by a slow-growing tumour of the epidermis of the skin which may involve the corneal or conjunctival epithelium. Coats' disease Chronic, progressive retinal vascular anomalies, usually unilateral, occurring predominantly in young males. It is characterized by retinal exudates, irregular dilatation (telangiectasia) and tortuosity of retinal vessels and appears as a whitish fundus reflex (leukocoria). Subretinal haemorrhages are frequent and eventually retinal detachment may occur. The main symptom is a decrease in central or peripheral vision, although it may be asymptomatic in some patients. Management may involve photocoagulation or cryotherapy. A less severe form of the disease is called Leber's miliary aneurysms. Syn. retinal telangiectasia. Crohn's disease A type of inflammatory, chronic bowel disease characterized by granulomatous inflammation of the bowel wall causing fever, diarrhoea, abdominal pain and weight loss. The ocular manifestations include acute iridocyclitis, scleritis, conjunctivitis and corneal infiltrates. Devic's disease A demyelinative disease of the optic nerve, the optic chiasma and the spinal cord characterized by a bilateral acute optic neuritis with a transverse inflammation of the spinal cord. Loss of visual acuity occurs very rapidly and is accompanied by ascending paralysis. There is no treatment for this disease. Syn. neuromyelitis optica. Eales' disease A non-specific peripheral retinal periphlebitis (i.e. an inflammation of the outer coat of a vein) that usually affects mostly young males, often those who have active or healed tuberculosis. It is characterized by recurrent haemorrhages in the retina and vitreous. This disease is a prime example of retinal vasculitis. Fabry's disease An X-linked recessive disease caused by mutations in the gene encoding alpha-galactosidase A (GLA) and characterized by an abnormal accumulation of glycolipid in the tissues. It appears as small purple skin lesions on the trunk and there may be renal and cardiovascular abnormalities. Ocular signs include whorl-like corneal opacities, star-shaped lens opacities, and tortuous conjunctival and retinal blood vessels. Graves' disease An autoimmune disorder in which immunoglobulin antibodies bind to thyroid-stimulating hormone receptors in the thyroid gland and stimulate secretion of thyroid hormones leading to hyperthyroidism. The main ocular manifestations (called Graves' ophthalmopathy) are exophthalmos, retraction of the eyelids (Dalrymple's sign), conjunctival hyperaemia, lid lag in which the upper lid follows after a latent period when the eye looks downward (von Graefe's sign), defective eye movements (restrictive myopathy) and optic neuropathy, besides increased pulse rate, tremors, loss of weight and diarrhoea. It typically affects women between the ages of 20 and 50 years. Most common signs associated with the disease are those of von Graefe and Moebius. Syn. thyrotoxicosis. If only the eye signs of the disease are present without clinical evidence of hyperthyroidism, the disease is called euthyroid or ophthalmic Graves' disease. Treatment begins with control of the hyperthyroidism (if present). Some cases may recover spontaneously with time. Mild cases of ocular deviations and restrictions may benefit from a prismatic correction. Corticosteroids and radiotherapy may be needed and surgery is a common form of management, especially when there is diplopia in the primary position of gaze. See accommodative infacility; exophthalmos; thyroid ophthalmopathy. Harada's disease A disease characterized by bilateral exudative uveitis associated with alopecia, vitiligo and hearing defects. However, as many aspects of this entity overlap clinically and histopathologically with the Vogt-Koyanagi syndrome it is nowadays combined and called the Vogt-Koyanagi-Harada syndrome. von Hippel's disease A rare disease, sometimes familial, in which haemangiomata occur in the retina where they appear ophthalmoscopically as one or more round, elevated reddish nodules. The condition is progressive and takes years before there is a complete loss of vision. Syn. angiomatosis retinae. von Hippel-Lindau disease Retinal haemangioblastoma involving one or both eyes associated with similar tumours in the cerebellum and spinal cord and sometimes cysts of the kidney and pancreas. Ophthalmoscopic examination shows a reddish, slightly elevated tumour. Leber's disease See Leber's hereditary optic atrophy. Niemann-Pick disease An autosomal recessive inherited lipid storage disorder characterized by a partial destruction of the retinal ganglion cells and a demyelination of many parts of the nervous system. It is caused by mutation in the NPC1 gene. The condition usually involves children of Jewish parentage. When the retina is involved, there is a reddish central area (cherry-red spot) surrounded by a white oedematous area. The disease usually leads to death by the age of two. This disease is differentiated from Tay-Sachs disease because of its widespread involvement and gross enlargement of the liver and the spleen. Syn. sphingomyelin lipidosis. See Tay-Sachs disease. Norrie's disease An inherited X-linked recessive disorder characterized by bilateral congenital blindness. It is caused by mutation in the norrin gene (NDP). The initial ocular presentation is leukocoria. It then progresses to cataract, corneal opacification and phthisis bulbi. The condition may be associated with mental retardation and hearing defects. Syn. oculoacoustico-cerebral degeneration; Andersen-Warburg syndrome. Oguchi's disease An autosomal recessive, inherited night blindness occurring mainly in Japan. All other visual capabilities are usually unimpaired but the patient presents an abnormal golden brown fundus reflex in the light-adapted state, which becomes a normal colour with dark-adaptation (Mizuo phenomenon). It is presumed to be due to an abnormality in the neural network of the retina. The disease can be caused by mutation in the arrestin gene (SAG) or the rhodopsin kinase gene (GRK1).ophthalmic Graves' d. See Graves' disease. Paget's disease Hereditary systemic disorder of the skeletal system accompanied by visual disturbances, the most common being retinal arteriosclerosis. See angioid streaks; arteriosclerosis. von Recklinghausen's disease An autosomal dominant inherited disease with a gene locus at 17q11. It is caused by mutation in the neurofibromin gene. It is characterized by tumours in the central nervous system and in cranial nerves, enlarged head, 'café au lait' spots on the skin, choroidal naevi, optic nerve glioma, peripheral neurofibromas (e.g. on the eyelid) and Lisch nodules. Glaucoma may occur. Syn. neurofibromatosis type 1 (NF-1). Refsum's disease See Refsum's syndrome. Reiter's disease A systemic syndrome characterized by a triad of three diseases: urethritis, arthritis and conjunctivitis. Keratitis and iridocyclitis may follow as complications. It occurs mainly in young men typically following urethritis and less commonly after an attack of dysentery or acute arthritis, which usually affects the knees, ankles and Achilles tendon. Syn. Reiter's syndrome. Sandhoff's disease An autosomal recessive inherited disease similar to Tay-Sachs disease with the same signs, but differing in that both the enzymes hexosaminidase A and B are defective and it develops more rapidly and can be found among the general population. The main ocular manifestation is a whitish area in the central retina with a cherry-red spot which eventually fades and the optic disc develops atrophy. Syn. Gm2 gangliosidosis type2. sickle-cell disease A hereditary anaemia encountered among black and dark-skinned people due to a defect in the haemoglobin. It is characterized by retinal neovascularization, haemorrhages and exudates, cataract and subconjunctival haemorrhage. Syn. sickle-cell anaemia. Spielmeyer-Stock disease See Batten-Mayou disease. Stargardt's disease An autosomal recessive inherited disorder of the retina occurring in the first or second decade of life and affecting the central region of the retina. A few cases are inherited as an autosomal dominant trait. Known causes of the disease include a mutation in one of the following genes: ABCA4, CNGB3 and ELOVL4. There is an accumulation of lipofuscin within the retinal pigment epithelium, which interferes with its function. With time a lesion develops at the macula, which has a 'beaten-bronze' reflex. It is often surrounded by yellow-white flecks. There is a loss of central vision but peripheral vision is usually normal. Myopia is very common. Management usually consists of a high plus correction for near to magnify the retinal image and wearing UV-protecting sunglasses. Syn. Stargardt's macular dystrophy. See macular dysrophy; fundus flavi-maculatus. Steinert's disease See myotonic dystrophy. Still's disease See juvenile rheumatoid arthritis. Sturge-Weber disease See Sturge-Weber syndrome. Tay-Sachs disease An autosomal recessive lipid storage disorder caused by a deficiency of the enzyme hexosaminidase A which leads to an accumulation of Gm2 ganglioside (a fatty acid derivative) in the ganglion cells of both the retina and the brain. It has its onset in the first year of life, vision is affected and the central retina shows a whitish area with a reddish central area (cherry-red spot), which fades and the optic disc develops atrophy. Eventually the eye becomes blind and death occurs, usually at about the age of 30 months. It affects Jewish infants more than others by a factor of about ten to one. Syn. Gm2 gangliosidosis type 1; infantile amaurotic familial idiocy. See Niemann-Pick disease. Terrien's disease See corneal ectasia. Wagner's disease See Wagner's syndrome. Wernicke's disease A disease characterized by disturbances in ocular motility, pupillary reactions, nystagmus and ataxia. It is mainly due to thiamin deficiency and is frequently encountered in chronic alcoholics. Syn. Wernicke's syndrome. Wilson's disease A systemic disease resulting from a deficiency of the alpha-2-globulin ceruloplasmin beginning in the first or second decade of life. It is characterized by widespread deposition of copper in the tissues, tremor, muscular rigidity, irregular involuntary movements, emotional instability and hepatic disorders. The ocular features are degenerative changes in the lenticular nucleus and most noticeably a Kayser-Fleischer ring. Syn. hepatolenticular degeneration; lenticular progressive degeneration; pseudosclerosis of Westphal. Millodot: Dictionary of Optometry and Visual Science, 7th edition. © 2009 Butterworth-Heinemann disease Medtalk 1. A condition in which bodily functioning is interfered with or damaged, resulting in characteristic signs and symptoms 2. The loss of a state of wellness due to a either a failure in physiologic adaptation mechanisms or an overwhelming of the natural defenses by a noxious agent or pathogen. See Acute disease, Adjuvant disease, Addison's disease, 'Aguecheek's disease, ' AIDS-defining disease, Air travel disease, Akureyri disease, Alcoholic liver disease, Aleutian mink disease, Alpha heavy chain disease, Alzheimer's disease, Anchor disease, Anterior horn disease, Asbestos airways disease, Atherosclerotic heart disease, Atypical GERD, Autoimmune disease, Bachelor's disease, Batten's disease, Behçet's disease, Best's disease, Bird handler's disease, Black cardiac disease, Black liver disease, Black lung disease, Blount's disease, Blue disease, Borna disease, Bornholm disease, Bowen's disease, Bread & butter disease, Brill-Zinsser disease, Brisket disease, Brown-Symmers disease, Bubble & hole disease, Bubble boy disease, Bulky disease, Bullous disease, Caffey disease, CAG disease, Caisson disease, Calcium pyrophosphate deposition disease, Canavan's disease, Caroli's disease, Castleman's disease, Cat scratch disease, Catabolic disease, Cave disease, Celiac disease, Central core disease, Cerebrovascular disease, Chaga's disease, Charcot-Marie-Tooth disease, Cheese-washer's disease, Christian-Weber disease, Christmas disease, Chronic disease, Chronic Lyme disease, Circling disease, Clinical disease, Coats' disease, Cold agglutinin disease, Collagen vascular disease, Communicable disease, Complex disease, Complicated disease, Congenital heart disease, Connective tissue disease, Constitutional disease, Controlled disease, Coronary artery disease, Creutzfeldt-Jakob disease, Crohn's disease, Crouzon's disease, Crumpled bone disease, Cushing's disease, Cytomegalic inclusion disease, Deficiency disease, Degenerative joint disease, Delta heavy chain disease, Dense deposit disease, Dent's disease, Dialysis-associated cystic disease, Disappearing bone disease, Disialotransferrin developmental disease, Dread disease, Dual diagnosis disease, Eales' disease, Ebola disease, End-stage renal disease, Endemic disease, Environmental disease, Environmental lung disease, Ethnic disease, Evaluable disease, Exanthematous viral disease, Extrapyramidal disease, Fabry's disease, Fahr disease, Fibrocystic disease, Fifth disease, Finger & toe disease, Fish-eye disease, Foot & mouth disease, 'Foot-in-mouth disease.', Forestier's disease, Fourth disease, Fox den disease, Freiberg disease, Fulminant disease, Fyrn's disease, G protein disease, Gamma heavy chain disease, Gastroesophageal reflux disease, Gaucher type 1 disease, Genetic disease, Gestational trophoblastic disease, Glycogen storage disease, Goldstein's disease, Goodpasture's disease, Graft-versus-host disease, Graves' disease, Green urine disease, Gum disease, Haff disease, Hailey-Hailey disease, Hand-Schüller-Christian disease, Hard metal lung disease, Hartnup disease, Heart disease, Heat stress disease, Heavy chain disease, Hemolytic disease of newborn disease, Hemorrhagic disease of the newborn, Hirschsprung's disease, His disease, Hodgkin's disease, Hoffa's disease, Human adjuvant disease, Huntington's disease, Hyaline membrane disease, Hydatid cyst disease, Hydroxyapatite deposition disease, Hyperendemic disease, Hypertensive cardiovascular disease, I cell disease, Iceland disease, Idiopathic midline destructive disease, Immune complex disease, Inflammatory bowel disease, Interesting disease, Interstitial kidney disease, Interstitial lung disease, Ischemic disease, Isobaric counterdiffusion gas lesion disease, Japanese cerebrovascular disease, Jodbasedow disease, Katayama disease, Kawasaki's disease, Keshan disease, Kikuchi's disease, Kimmelstiel-Wilson disease, Kimura's disease, Kinky hair disease, Kissing disease, Kohler's disease, Kuf's disease, Kyasanur forest disease, Lafore's disease, Legg-Perthes disease, Legionnaire's disease, Leigh's disease, Letterer-Siwe disease, Lifestyle disease, Light chain disease, Light chain deposition disease, Limb-girdle disease, Lipid storage disease, Little's disease, Liver disease, Localized disease, Low motion disease, Lyme disease, Lysosomal storage disease, Machado-Joseph disease, Maple syrup urine disease, Marble bone disease, Marburg disease, Margarine disease, Maroteaux-Lamy disease, McArdle's disease, McCune-Albright disease, Measurable disease, Medullary cystic disease, Ménière's disease, Meningococcal invasive disease, Metabolic bone disease, Metastatic disease, Microvillus inclusion disease, Minamata disease, Minimum change disease, Mitochondrial disease, Mixed connective tissue disease, Molecular disease, Most litigated disease, Motor neuron disease, Moya-moya disease, Mseleni disease, Mu chain disease, Multiple concurrent disease, Multivessel disease, Nantucket disease, Neutral lipid storage disease, Newcastle disease, Non-alcoholic fatty liver disease, Norrie's disease, Notifiable disease, Oasthouse urine disease, Obesity-related disease, Obstructive airways disease, Oguchi's disease, 'Oid-oid disease', Orphan disease, Osgood-Schlatter disease, Paget's disease of bone, Paget's disease of breast, Paget's extramammary disease, Parkinson's disease, Pathologists' disease, Pelvic inflammatory disease, Pendular disease, Periodontal disease, Peripheral vascular disease, Peroxisomal disease, Pet-associated disease, Peyronie's disease, Phagocytic disease, Pick's disease, Pigeon breeders' disease, Pink disease, Plummer's disease, Polycystic kidney disease, Polycystic liver disease, Polycystic ovarian disease, Polygenic disease, Post-transfusion graft-versus-host disease, Preimplantation genetic disease, Proliferative breast disease, Pseudo-Hirschprung's disease, Pseudo-Whipple's disease, Pseudo-von Willebrand disease, Psychosomatic disease, Pulmonary veno-occlusive disease, Quincke's disease, Ragged red fiber disease, Reactive hemophagocytic disease, Receptor disease, Redmouth disease, Red pulp disease, Red urine disease, Re-emerging disease, Refsum's disease, Regional disease, Reportable occupational disease, Residual disease, Restrictive lung disease, Rheumatic heart disease, Rickettsial disease, Rippling muscle disease, Ritter's disease, Round heart disease, Runt disease, Saint disease, Salla disease, SC disease, Schindler's disease, Seever's disease, Self-limited disease, Seventh-day disease, Sex-linked disease, Sickle cell disease, Silicone-reactive disease, Silo-filler's disease, Single-gene disease, Sixth disease, Slavic-type Wilson's disease, Slim disease, Small airways disease, Small duct disease, Small vessel disease, SS disease, Stable disease, Stargardt's disease, Still's disease, Storage disease, Storage pool disease, Tea-drinker's disease, Thatched roof disease, Transfusion-associated graft-versus host disease, Trinucleotide repeat disease, Tsutsugamushi Scrub typhus disease, Undifferentiated connective tissue disease, Uremic heart disease, Vagrant's disease, Valvular heart disease, Vector-borne disease, Veno-occlusive disease, Virgin's disease, Von Hippel-Lindau disease, Von Recklinghausen's disease, Warm agglutinin disease, Water-borne disease, Whipple's disease, White's disease, White muscle disease, White pulp disease, Wilson's disease, Winter vomiting disease, Wolman's disease, Woolly hair disease, Woringer-Kolopp disease, X disease, X-linked lymphoproliferative disease, Yellow disease, Yellow fat disease, Yellow ovary disease, Yu-Cheng oil disease, Zollinger-Ellison disease.
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